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Химия Химия
Органическая химия Органическая химия


Presynaptic control of sensory input on the mammalian olfactory system. In vivo modulation of olfactory receptor neuron input to the mouse olfactory bulb by tonic and activity-dependent presynaptic inhibition

Автор:   Nicolas P.
мягкая обложка
132 страниц
2009 год
Издательство:   Книга по Требованию
2382 руб
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Описание:Presynaptic inhibition could function to limit the strength of olfactory input to the central nervous system, as well as provide a substrate for centrifugal control of odorant representations early in the olfactory system. Odorant and electrical stimulation combined with in vivo pharmacology were used to characterize the functional determinants of GABAB-mediated presynaptic. Presynaptic inhibition modulates signal transmission in the olfactory pathway by several mechanisms, a major one being mediated by GABAB receptors, which suppress presynaptic calcium influx and subsequent transmitter release from the receptor neuron terminal. When the behavioral state of the awake animal was altered, odorant-evoked responses were affected. The results of this work showed that tonic inhibition is a major determinant of receptor input strength; and were dependent on glutamatergic transmission from second-order neurons in the glomerular layer. Taken together these results suggest that tonic inhibition via top-down, centrifugal control plays a major role in modulating the magnitude of sensory input to the brain as a function of behavioral state.

Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

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Miracles of the Gods

They attribute to hysterics 'a marked desire to be honoured, loved, praised and recognized, and also their joy in the ability to attract people to them by their own charms ... and in this way explain why the religious martyrs not only bore their martyrdom but also went to meet it gladly'. In addition there is the frequently proved fact that hysterics are virtually insensible to pain. In my opinion the brief description of the clinical pictures gives essential hints about the predisposed state of people who are sought out by stigmata. All three symptoms of illness point to damage or disturbance of the nervous system. Simple reference books describe a 'stigmatic' as a man with a hypersensitive nervous system who tends to react to psychic and other stimuli with disorders (stigmata.) The parasympatheticus, a part of the vegetative nervous system, acting on stimuli or orders from the brain, makes the eyelids close, tears flow and spittle run, but it also controls the sexual organs, etc. In a state of heightened tension (vagotonia) the organs looked after by the para-sympathetic nervous system require very small stimuli; organic disorders can arise ...»

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