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Generation and analysis of endothelial-targeted transgenic mouse lines over-expressing human GTP cyclohydrolase 1 Tetrahydrobiopterin and nitric oxide synthase regulation.

Автор:   Nicholas A.
мягкая обложка
140 страниц
2009 год
Издательство:   Книга по Требованию
Цена:
2382 руб
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Описание:These findings suggest that strategies to augment endothelial BH4 levels, either by increased biosynthesis or by reducing BH4 oxidation, may be valuable in preventing and treating vascular disease. In this project novel targeted transgenic mouse lines were generated with endothelial-specific over-expression of human GTPCH. Modest persistent increases in endothelial cell BH4 concentration by increased biosynthesis are sufficient to maintain NO bioavailability and endothelial function, even in the setting of vascular oxidative stress. Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is a key mediator of vascular homeostasis. eNOS enzymatic activity appears to be determined by the availability of its cofactor tetrahydrobiopterin (BH4). These studies have shown that BH4 bioavailability within the endothelium is essential for maintaining NO synthesis and reducing superoxide production by eNOS in vivo. BH4 bioavailability is limited by oxidative degradation in dysfunctional endothelium, and by alterations in the rate of its biosynthesis, governed by the rate-limiting enzyme GTP cyclohydrolase 1 (GTPCH).


Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

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The Rise and Fall of the Third Chimpanzee. Evolution and Human Life

Since the Tasmanians' sole boats were rafts capable of only short journeys, they had had no contact with any other humans since the rising sea level cut off Tasmania from Australia 10,000 years ago. Confined to their private universe for hundreds of generations, they had survived the longest isolation in modern human history—an isolation otherwise depicted only in science fiction. When the white colonists of Australia finally ended that isolation, no two peoples on Earth were less equipped to understand each other than were Tasmanians and whites. The tragic collision of these two peoples led to conflict almost as soon as British sealers and settlers arrived around 1800. Whites kidnapped Tasmanian children as labourers, kidnapped women as consorts, mutilated or killed men, trespassed on hunting grounds, and tried to clear Tasmanians off their land. Thus, the conflict quickly focused on lebensraum, which throughout human history has been among the commonest causes of genocide. As a result of the kidnappings, the native population of northeast Tasmania in November 1830 had been reduced to seventy-two adult men, three adult women, and no children ...»

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DURING TRAUMA AND PARENTERAL FEEDING NITRIC OXIDE SYNTHASE IN PANCREATIC ISLETS.
Agents stimulating cyclic AMP/PKA i. e. PACAP27 and PACAP38 were capable of not only inhibiting neuronal NOS (ncNOS) but also counteracting the expression of iNOS induced by intralipid infusion.
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MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION. New findings about GTN-derived nitric oxide formation
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Cutaneous Nitric Oxide Production. Its role in man
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Wirksamkeit von all-trans-Retinolsaeure auf Neuroblastomzellen. Regulation der Expression von PI3-Kinasen unter Einwirkung von all-trans-Retinolsaeure auf Neuroblastomzellen
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Structural properties are thereby manipulated with a minimum of experimental efforts while dramatic changes can be observed from the nanometer to the millimeter range.
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A Comparative Analysis between the UK, Germany, Italy and the US The Role of the External Auditor in Bank Regulation and Supervision.
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Regulation of the Krueppel-like Factor 6 Tumor Suppressor. Ras Promotes Cancer Cell Growth via Alternative Splicing-Mediated Inactivation of KLF6
KLF6 directly binds DNA at GC box promoter elements.
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Wild-type and mutant isoforms of PPP1R11/inhibitor 3 (I3), PPP1R2/inhibitor 2 (I2) and a novel protein similar to I2 were studied.
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