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Химия Химия
Органическая химия Органическая химия


Molecular Markers Associated with Hepatotoxicity. Development of in vitro test system based on human cells

Автор:   Krzysztof W.
мягкая обложка
208 страниц
2009 год
Издательство:   Книга по Требованию
3188 руб
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Описание:Pharmaceutical and, to a lesser degree, most other consumer products are routinely tested for safety. Testing of drugs can be performed for hours or weeks/months to follow acute or chronic toxicity respectively. As a consequence results of toxicological studies in animals can lead to false conclusions and termination of development of drug candidates potentially beneficial to humans and also to continued development of drug candidates that later show to be toxic to humans. This book presents development of an in vitro human cells based test system that is suitable for pre-clinical studies of drugs and assessment of adverse effects of various chemical compounds. Traditionally preclinical toxicological studies are performed on animals. The system is based on rotary vessels that simulate growth in microgravity conditions allowing the cells to grow continuously for months and create cell conglomerates that resemble normal liver tissue. Metabolism of drugs and toxic compounds in many cases is different in test animals and humans.

Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

2990 руб
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The Emerging Mind: The Reith Lectures 2003

OK why did they ignore it? Because nobody could think of a candidate mechanism. How can you possibly encode heredity in a chemical until Watson and Crick came along, described the double helical structure of DNA, described the genetic code and then people started accepting it, and recognised the importance of bacterial transformation. So I'd like to do the same thing with synesthesia. First of all I'd like to show it's real, it's not bogus. Second, suggest candidate mechanisms, what's going on in the brain. And third, so what - why should I care? So I'm going to argue in fact synesthesia has very broad implications. It might tell you about things like metaphor and how language evolved in the brain, maybe even the emergence of abstract thought that us humans, human beings are very good at. So first we need to show synesthesia is a real phenomenon. What we did was essentially develop a clinical test for discovering closet synesthetes, and how do you do that? First of all we found two synesthetes and these people saw numbers as colour, for example five as red and two as green, so we produced a computerised display on the screen which had a random jumble of fives on the screen and embedded among these fives are a number of twos, and the twos are arranged to form a shape like a triangle or a square or a circle ...»

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Biotechnology in Agriculture. Utilization of Molecular markers in Mango (Mangifera indica L.)
Constructed dendrograms for results ,individually or collectively, revealed that similarity and clustering is dependant on the marker system used.
          2005 руб             2008 год          104 стр.          мягкая обложка

Inheritance and Molecular Marker-Based Genetic Mapping Breeding Parthenocarpic Cucumber.
New research areas need to be explored for yield improvement.
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Quantity and quality of chemicals present in the genus vary species to species.
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          1978 руб             2009 год          104 стр.          мягкая обложка

Interactions occurring between various bacteria and fungi in the burn wound are also analyzed, which may altogether alter the clinical prognosis of the patient.
          2766 руб             2009 год          188 стр.          мягкая обложка

Metal complexes of N-heterocyclic carbene. Silver, mercury, ruthenium and palladium complexes of N-heterocyclic carbene-linked cyclophanes: synthesis, molecular structures and characterization
This book describes the synthesis and isolation of silver, mercury, ruthenium and palladium complexes of bidentate NHCs, derived from imidazolium-linked cyclophanes and related bis-imidazolium salts.
          2766 руб             2009 год          164 стр.          мягкая обложка

Molecular Dissection of the Clonal M1T1 Group A Streptococci. Integrating Genomics, Proteomics, and Bioinformatics Tools to Define the Unique Features of a Pandemic Flesh-Eating Bacterial Strain
The resurgence of the severe diseases was thus suspected to be a result of an unusual pathogenic potential inherent to the few reemerging strains.
          2766 руб             2009 год          164 стр.          мягкая обложка

Molecular Approach to Gram-positive Rod Identification DNA Sequencing Experience in Clinical Laboratory.
This study shows that 16S rRNA gene sequencing, which can be done in less than 10 hours for $62. 53 per isolate, is more accurate, faster and, yet, cost effective comparing to conventional identification methods, especially when used for identification of Gram-positive rods with ambiguous biochemical profiles or slow growers.
          1994 руб             2009 год          88 стр.          мягкая обложка

p-groups of maximal class. Periodic structures in the graph associated with p-groups of maximal class
He gives a survey on the known structure of these groups and he proved two types of periodic patterns in the associated coclass graph.
          3212 руб             2009 год          132 стр.          мягкая обложка

College Drinking. Individual, Social, and Environmental Factors associated with Heavy Drinking among Undergraduate Students
The analyses presented provide insight into college life and should be particularly helpful to professionals in student affairs, alcohol researchers, and therapists or anyone else who has a curiosity about college drinking.
          3212 руб             2008 год          220 стр.          мягкая обложка

Functional Nanofibers from Functionalised p-Quaterphenylenes Organic Molecular Nanotechnology.
The organic nanofibers are grown in a self-assembly process to mutually aligned arrays on a muscovite mica substrate.
          2781 руб             2008 год          176 стр.          мягкая обложка

The Design of Interfacial Biomaterials and the Modulation of Galectin? 3 Aggregation With Multivalent Saccharide Ligands MOLECULAR INTERACTIONS AT THE CHEMISTRY-BIOLOGY INTERFACE.
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          2413 руб             2008 год          160 стр.          мягкая обложка

Contrastive Discourse Markers. An Examination of Their Characteristics in Korean
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          2781 руб             2009 год          172 стр.          мягкая обложка

Soybean Genes Associated With Low Palmitic and Low Linolenic Acid. In lines N97-3681-11 and N97-3708-13
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          2005 руб             2009 год          68 стр.          мягкая обложка

The post natal study looked at changes in laxity that took place in breast versus bottle feeding mothers.
          3231 руб             2009 год          248 стр.          мягкая обложка

The Metastasis Suppressor: Ndrg-1. Examining the Molecular Function and Iron Regulation of Ndrg-1 in Cancer
Furthermore, the ability of novel anti-cancer agents, the iron chelators, to up- regulate Ndrg-1 was also explored.
          2413 руб             2009 год          140 стр.          мягкая обложка

Cancer Over-expressed Receptors as Targets for PET Molecular Imaging. Androgen and Epidermal Growth Factor (EGF) Receptors as Targets for Molecular Imaging of Cancer Using Positron Emission Tomography (PET)
Epidermal growth factor receptor (EGFR) is involved in proliferation, cell movement, cell survival and differentiation of both normal and malignant cells.
          2413 руб             2009 год          136 стр.          мягкая обложка

The Literary and the Theological Functions of NT Miracle Narratives. The Miracle Narratives Associated with Jesus and the Apostles in Light of Their Counterparts in the Old Testament
Elijah and Elisha are the links between the two.
          2413 руб             2010 год          124 стр.          мягкая обложка

Inheritance of Congenital Blindness. Genetic Epidemiological and Molecular Perspectives of Congenital Blindness at family level
          2005 руб             2009 год          108 стр.          мягкая обложка

Factors Associated with Late Presentation to Chronic HIV Care. Prevalence of and Factors Associated with Late Presentation to Chronic HIV Care in Dessie Referral Hospital, North East Ethiopia
Highly active antiretroviral therapy was the breakthrough in care and treatment of people living with HIV, leading to a reduction in mortality and an improvement in the quality of life.
          2005 руб             2010 год          72 стр.          мягкая обложка

HIV prevalence and associated factors among University students:. University students, 2009
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          2005 руб             2010 год          64 стр.          мягкая обложка

Object, Definite, or Focus Markers? Non-Subject Agreement Elements in Amharic Relative Clause.
This work examines their nature and function in structures of relative clauses.
          2413 руб             2010 год          132 стр.          мягкая обложка

A comparison of molecular changes in casein micelles. of buffalo and cow milk under different physico-chemical conditions
Buffalo milk is the second most produced milk in the world after cow milk with ~13% contribution in the world’s milk production.
          3231 руб             2010 год          264 стр.          мягкая обложка

PHYSICOCHEMISTRY AND HYDRODYNAMICS OF LANGMUIR-BLODGETT DEPOSITIONS. Influence of Molecular Level Forces on the Efficiency of Deposition of Perfectly Ordered Langmuir Nanofilms
By the Langmuir-Blodgett (LB) technique, films of precise thickness and controlled molecular architecture and order can be obtained.
          2781 руб             2008 год          176 стр.          мягкая обложка

Leisure Activities in Rheumatoid Arthritis. Associated Factors and Assessment
Quality of life is affected if the most important leisure activities are lost.
          2005 руб             2008 год          72 стр.          мягкая обложка

Conjugated Linoleic Acid Reduces Inflammation in Animal Models. Evidence of a Molecular Mechanism
Conjugated linoleic acid (CLA) isomers are naturally occurring dietary fatty acids derived primarily from microbial biohydrogenation of linoleic acid.
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Cold Trapped Molecular Ions. Production, Manipulation, and Spectroscopy
The book summarizes the main lines of research in cold trapped molecular ion physics, thus, making it useful as an introduction for advanced students and experienced researchers.
          2005 руб             2008 год          84 стр.          мягкая обложка

Genotype and Environment interaction (GxE) in Sugarcane analyzed through Additive Main effects and Multiplicative Interaction (AMMI) model MORPHO-PHYSIOLOGICAL CHARACTERS ASSOCIATED WITH GXE IN SUGARCANE.
In fact, there are two broad categories of breeding strategies in crops: broad adaptation and location-specific adaptation.
          2413 руб             2009 год          156 стр.          мягкая обложка


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