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Химия Химия
Органическая химия Органическая химия

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Molecular Markers Associated with Hepatotoxicity. Development of in vitro test system based on human cells

Автор:   Krzysztof W.
мягкая обложка
208 страниц
2009 год
Издательство:   Книга по Требованию
Цена:
3188 руб
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Описание:Pharmaceutical and, to a lesser degree, most other consumer products are routinely tested for safety. Testing of drugs can be performed for hours or weeks/months to follow acute or chronic toxicity respectively. As a consequence results of toxicological studies in animals can lead to false conclusions and termination of development of drug candidates potentially beneficial to humans and also to continued development of drug candidates that later show to be toxic to humans. This book presents development of an in vitro human cells based test system that is suitable for pre-clinical studies of drugs and assessment of adverse effects of various chemical compounds. Traditionally preclinical toxicological studies are performed on animals. The system is based on rotary vessels that simulate growth in microgravity conditions allowing the cells to grow continuously for months and create cell conglomerates that resemble normal liver tissue. Metabolism of drugs and toxic compounds in many cases is different in test animals and humans.


Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

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The Emerging Mind: The Reith Lectures 2003

OK why did they ignore it? Because nobody could think of a candidate mechanism. How can you possibly encode heredity in a chemical until Watson and Crick came along, described the double helical structure of DNA, described the genetic code and then people started accepting it, and recognised the importance of bacterial transformation. So I'd like to do the same thing with synesthesia. First of all I'd like to show it's real, it's not bogus. Second, suggest candidate mechanisms, what's going on in the brain. And third, so what - why should I care? So I'm going to argue in fact synesthesia has very broad implications. It might tell you about things like metaphor and how language evolved in the brain, maybe even the emergence of abstract thought that us humans, human beings are very good at. So first we need to show synesthesia is a real phenomenon. What we did was essentially develop a clinical test for discovering closet synesthetes, and how do you do that? First of all we found two synesthetes and these people saw numbers as colour, for example five as red and two as green, so we produced a computerised display on the screen which had a random jumble of fives on the screen and embedded among these fives are a number of twos, and the twos are arranged to form a shape like a triangle or a square or a circle ...»

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