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Gene therapy of bladder cancer and colorectal metastasis in the liver. Isulin like growth factor 2 P3 and P4 regulatory sequences controlled suicidal therapy of cancer cells

Автор:   Basim A.
мягкая обложка
156 страниц
2009 год
Издательство:   Книга по Требованию
Цена:
2382 руб
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Описание:This book describes a PhD research in which the regulatory sequences of IGF2 (P3 and P4 promoters) were used to induce killing of cancer cells in culture or cell of mouse and rat bladder TCCs and of rat colon metastasis to the liver. IGF2 plays a role in tumor development. IGF2 gene was found to be differentially overexpressed in malignant compaired to normal bladder tissue. Such vectors were successfully shown in this work to selectively kill malignant tissue both in vitro and in vivo. It favors cancer cells survival, progression and metastatic ability of the tumor in an autocrine/paracrine fashion. Therefore, by selective killing of cancer cells, which overexpress IGF2, the neighboring non- IGF2 producing tumor cells are at least partly deprived of their IGF2 supply and thus amplifying the therapeutic potential of IGF2 promoters driven vectors. On the basis of the findings presented in this book, a patient oriented approach to treat TCC and colon metastasis in liver is proposed. Moreover, IGF2 mRNA and protein levels were previously shown to be highly upregulated in primary colorectal cancer and in colon metastasis to the liver.


Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

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Мутанты. О генетической изменчивости и человеческом теле

Cell 75: 431-441 Donnai D. and R.M. Winter. 1989. Disorganisation: a model for 'early amnion rupture'? Journal of Medical Genetics 26: 421-425. Dreger, A.D. 1998. Hermaphrodites and the medical invention of sex. Harvard University Press. Cambridge, Mass. Dudley, A.T. et al. 2002. A re-examination of proximodistal patterning during vertebrate development. Nature 418: 539-544 Durham-Pierre, D. et al. 1994. African origin of an intragenic deletion of the human P gene in tyrosine positive oculocutaneous albinism. Nature Genetics 7: 176-179 Egenvall, A. et al. 2000. Age pattern of mortality in eight breeds of insured dogs in Sweden. Preventative Veterinary Medicine 46: 1-14 Eigenmann, J.E. 1987. Insulin-like growth factor 1 in dogs. Frontiers of Hormone Research 1 7: 161-172 Eigenmann, J.E. et al. 1988. Insulin-like growth factor 1 levels in proportionate dogs, chondrodystrophic dogs and in giant dogs. Acta Endocrinologica (Copenhagen) 118: 105-108 Eigenmann J.E. et al. 1984. Body size parallels insulin-like growth factor 1 levels but not growth hormone secretory capacity ...»

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