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Gene therapy of bladder cancer and colorectal metastasis in the liver. Isulin like growth factor 2 P3 and P4 regulatory sequences controlled suicidal therapy of cancer cells

Автор:   Basim A.
мягкая обложка
156 страниц
2009 год
Издательство:   Книга по Требованию
2382 руб
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Описание:This book describes a PhD research in which the regulatory sequences of IGF2 (P3 and P4 promoters) were used to induce killing of cancer cells in culture or cell of mouse and rat bladder TCCs and of rat colon metastasis to the liver. IGF2 plays a role in tumor development. IGF2 gene was found to be differentially overexpressed in malignant compaired to normal bladder tissue. Such vectors were successfully shown in this work to selectively kill malignant tissue both in vitro and in vivo. It favors cancer cells survival, progression and metastatic ability of the tumor in an autocrine/paracrine fashion. Therefore, by selective killing of cancer cells, which overexpress IGF2, the neighboring non- IGF2 producing tumor cells are at least partly deprived of their IGF2 supply and thus amplifying the therapeutic potential of IGF2 promoters driven vectors. On the basis of the findings presented in this book, a patient oriented approach to treat TCC and colon metastasis in liver is proposed. Moreover, IGF2 mRNA and protein levels were previously shown to be highly upregulated in primary colorectal cancer and in colon metastasis to the liver.

Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

2990 руб
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Мутанты. О генетической изменчивости и человеческом теле

Cell 75: 431-441 Donnai D. and R.M. Winter. 1989. Disorganisation: a model for 'early amnion rupture'? Journal of Medical Genetics 26: 421-425. Dreger, A.D. 1998. Hermaphrodites and the medical invention of sex. Harvard University Press. Cambridge, Mass. Dudley, A.T. et al. 2002. A re-examination of proximodistal patterning during vertebrate development. Nature 418: 539-544 Durham-Pierre, D. et al. 1994. African origin of an intragenic deletion of the human P gene in tyrosine positive oculocutaneous albinism. Nature Genetics 7: 176-179 Egenvall, A. et al. 2000. Age pattern of mortality in eight breeds of insured dogs in Sweden. Preventative Veterinary Medicine 46: 1-14 Eigenmann, J.E. 1987. Insulin-like growth factor 1 in dogs. Frontiers of Hormone Research 1 7: 161-172 Eigenmann, J.E. et al. 1988. Insulin-like growth factor 1 levels in proportionate dogs, chondrodystrophic dogs and in giant dogs. Acta Endocrinologica (Copenhagen) 118: 105-108 Eigenmann J.E. et al. 1984. Body size parallels insulin-like growth factor 1 levels but not growth hormone secretory capacity ...»

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Точилка "Божья коровка", электрическая с контейнером (2 запасных лезвия EG-5009).
Электрические точилки помогут быстро, качественно и без каких-либо усилий заточить карандаши. А яркие и необычные дизайны порадуют детей и
451 руб
Раздел: Точилки
Макси-пазлы "Ягоды", 20 элементов.
Макси-пазлы разработаны специально для маленьких детей. Крупные крепкие детали удобны для захвата детской ручкой. А красочное оформление
426 руб
Раздел: Пазлы (Maxi)
Рюкзак "Basic. Чемпионат мира по футболу 2018", 30х41х13 см.
1 большое отделение с 1 внутренним отделением. 1 накладной карман спереди. Удобные лямки, позволяющие регулировать длину. Размер 30х41х13
1150 руб
Раздел: Канцтовары, хобби

Molecular investigations on archival tissues. Analysis of autopsies and biopsies from urinary bladder cancer collected since 1932
This monograph presents various methods for efficient extraction of DNA and protocols for sequencing (detection of gene mutations) from archival tissues.
          1978 руб             2009 год          104 стр.          мягкая обложка

Cancer Stories from the Woodland Cree. Exploring perceptions of cancer, health and illness in Northern Saskatchewan, Canada
Since limited information exists on the way cancer is perceived and experienced, the views of cancer, health and illness among the Woodland Cree were explored.
          2005 руб             2009 год          116 стр.          мягкая обложка

Application to a Bladder Cancer Case-Control Study Lifetime Exposure to Arsenic in Drinking Water.
Spatial, temporal, and spatio-temporal variability are incorporated in the assessment of lifetime exposure to arsenic.
          2413 руб             2007 год          332 стр.          мягкая обложка

On diseases of the liver
          1151 руб             2011 год          мягкая обложка

AAV-mediated gene therapy for renal tubulointerstitial fibrosis. HGF as a multifunctional anti-fibrotic agent with high impact on gene therapy for renal tubulointerstitial fibrosis
Therefore, in the present study HGF signaling and HGF induced expression profiles were studied in renal interstitial fibroblasts that represent a central cell type in tubulointerstitial fibrosis due to their prominent production of extracellular matrix proteins.
          3048 руб             2010 год          132 стр.          мягкая обложка

The Memoirs of Catherine the Great
This definitive new translation from the French is scrupulously faithful to her words and is the first for which translators have consulted original manuscripts written in Catherine’s own hand.
          1169 руб             2006 год          352 стр.          мягкая обложка

Two Years In The Forbidden City
          2 руб             178 стр.          мягкая обложка

Street Art Doodle Book: Outside the Lines
Luckily, some grown-ups never forget this, and thats why they become artists, so that the fun of making and doing never stops!
          1878 руб             2010 год          256 стр.          мягкая обложка

The life and revelations of Saint Gertrude, virgin and abbess, of the Order of St. Benedict
          1154 руб             2011 год          мягкая обложка

The Book of Mormon. Their Metal Plates, Our Paper Book
The Mormon migration to the American West is unparalleled in United States history.
          1891 руб             2010 год          92 стр.          мягкая обложка

Book of the New Sun 2: Sword and Citadel
          408 руб             2000 год          608 стр.          мягкая обложка

Search for Breast Cancer Susceptibility Genes. The Growth Hormone-1 / Insulin-like Growth Factor-1 Pathway and its Relationship to Breast Cancer
The work in this dissertation summarizes the investigation of polymorphisms in the GH1/IGF-1 axis in relation to breast cancer risk by means of the planning and conducting of case-control studies.
          2413 руб             2008 год          132 стр.          мягкая обложка

The Selfish Gene
          546 руб             2006 год          360 стр.          Мягкая обложка

Tumor Secreted grp170 as a Cancer Vaccine. Tumor secreted grp170 chaperones tumor antigens to the tumor microenvironment and induces an adaptive anti-tumor immune response
Although most chaperones are intracellular proteins they can be modified into secretory proteins.
          1978 руб             2009 год          92 стр.          мягкая обложка

Running Raw in the Wild The Cancer Emails.
There were days of despair and days of light. Cancer! The diagnosis used to be a death sentence!
          3188 руб             2008 год          296 стр.          мягкая обложка

Psychology and Alternative Therapies for Childhood ADHD. Psychologists Knowledge and Perceptions of the Efficacy of Complementary and Alternative Therapy for Children with ADHD
Knowledge of efficacy is fairly accurate, although, there appears to be some pessimism for interventions where there is minimal research.
          2400 руб             2009 год          128 стр.          мягкая обложка

Fruit and Vegetable Consumption and Risk of Epithelial Ovarian Cancer. A Comparative Analysis of the Impact of Calibration of Dietary Data in a Multi-Center Study
There was suggestive indication for a positive association with risk of ovarian cancer among very low fruit and vegetable consumers.
          2005 руб             2008 год          120 стр.          мягкая обложка

Exploring Differences in Breast Cancer Prognostic Factors. Health Disparities between Caucasian and African-American Women in the United States
Differences in breast cancer age at diagnosis, histology, and stage are present by race.
          2005 руб             2008 год          88 стр.          мягкая обложка

Regulation of the Krueppel-like Factor 6 Tumor Suppressor. Ras Promotes Cancer Cell Growth via Alternative Splicing-Mediated Inactivation of KLF6
KLF6 directly binds DNA at GC box promoter elements.
          2781 руб             2008 год          168 стр.          мягкая обложка

Play Away Stress!. The Use of Play Therapy Mediums in a Stress Management Programme With Corporate Employees
There is a growing need for corporate employees to be able to manage their stress levels and use stress to their own, and to the organisation’s, advantage.
          3231 руб             2009 год          300 стр.          мягкая обложка

Ascorbate Peroxidase Gene Family in Tomato. Identification and Characterization in the Cultivated Tomato and its Wild Relative Lycopersicon pennellii
It is also suggested that due to lineage-specific gene duplication and lose events, intricate phylogenetic relationships exist among the members of the Apx gene families.
          2005 руб             2009 год          80 стр.          мягкая обложка

Using the Non Depolarizing Neuromuscular Blocking Agent Vecuronium in Patients with Liver Dysfunction. Muscle Relaxants and Liver Dysfunction
There was no significant difference in the intubation score or onset time (time from the beginning of vecuronium administration till maximal neuromuscular block) between patients with or without liver dysfunction.
          2413 руб             2008 год          124 стр.          мягкая обложка

Irritable Bowel Syndrome and Chiropractic Spinal Manipulative Therapy. A study on the Effect of Chiropractic Manipulative Therapy in Conjunction with Allopathic Medication in the Management of Irritable Bowel Syndrome
The statistically significant improvement in the Global well-being, Quality of Life and significant decrease in the symptom frequency and bothersomeness is very encouraging indeed.
          3231 руб             2010 год          220 стр.          мягкая обложка

A series of methods are proposed in this book to to detect differentially expressed genes while controlling the false discovery rate.
          2413 руб             2010 год          136 стр.          мягкая обложка

The Force in Biology. Understanding and Measuring the Role of Cell Mechanics in Cancer and Aging
A few important questions remain: 1) what are the corresponding mechanical changes, 2) how do these mechanical changes help the cell adapt, 3) is it possible these adaptations result in unforeseen consequences, and 4) if so, do they result in disease? Due to technical limitations, only a portion of the answers have been explored to date. In an attempt to answer these questions, we present studies that use novel insights to quantify changes in cell and nuclear mechanics and reveal the potential impact forces play in cancer and aging. Mechanical adaptations in response to forces have been studied mainly though visualization of changes in cytoskeletal structures and understanding the corresponding signaling pathways. These observations are informative in elucidating regulating proteins and cellular phenotype, but do not offer insights to the effects, or cell mechanics, of these cellular changes and regulations. Understanding forces in the context of biology is essential as all cells in the human body are constantly subjected to mechanical forces and are often presented with situations where adaptations are critical for survival.
          2781 руб             2008 год          172 стр.          мягкая обложка

ROS and Antioxidant Systems in Apoptosis. Oxidant Balance in Cell Death and Cancer Therapy
In healthy individuals, antioxidant systems serve to maintain intracellular ROS levels below a certain threshold, permitting the functionality of essential ROS-mediated signaling processes but preventing ROS overproduction and potential tissue damage.
          2413 руб             2008 год          132 стр.          мягкая обложка

Berberis lycium reduces Serum Cholesterol in Broiler. An extensive work on the affect of Berberis lycium on the growth, immunity, liver function and serum cholesterol levels in broilers
B lycium infusion did not affect HDL level in serum, however LDL was significantly (P<0. 001) affected and was lower in group-C. It was concluded that Berberis lycium added to feed at the rate of 2% or watered as aqueous extract at the rate of 1% can be used in broiler production for optimum performance from economic point of view, for reducing serum total cholesterol, triglyceride and LDL and improving immunity against IBD and ND. Serum cholesterol and LDL decreased with increasing B lycium up to 2% (p<0. 05) while HDL increased.
          2413 руб             2010 год          144 стр.          мягкая обложка

When Psychological Therapy Is Unsuccessful:. A Grounded Theory of Clients' Experiences Reveals "The Client's Helical Path"
          3231 руб             2008 год          244 стр.          мягкая обложка

Infection, Immunity and Serum Therapy in Relation to the Infectious Diseases of Man
          1751 руб             2011 год          мягкая обложка


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