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Numerical modeling of blood flow in human left coronary artery and in vitro study of endothelial cell activation by shear stress Estimation of coronary wall shear and endothelial cell activation.

Автор:   Saravan K.S.
мягкая обложка
120 страниц
2009 год
Издательство:   Книга по Требованию
Цена:
1994 руб
отсутсвует
на складе

способы доставки и оплаты
Описание:The shear stress history from normal, 80% stenosis and inside the recirculation zone(downstream throat) was exported into a cone and plate hemodynamic cell shearing device. The low oscillating WSS inside the recirculation zone activated the EC and increased the ICAM-1 expression. The scope of this study was to estimate the wall shear stress (WSS) distribution inside the human left anterior descending (LAD) coronry artery and understand the behavior of endothelial cells (EC) under these shear levels. 2D and 3D models of LAD under normal and disease conditions (30%, 60% and 80% severity) were discretized and analyzed using CFD (Fluent v6. 3. 26,Ansys). As the disease severity increased, a disturbed WSS distribution near the throat region was observed. Thus the disturbed wall shear stress near the stenosis throat activates endothelial cells and leads to inflammatory responses. The EC activation due to shear was measured based on the amount of intercellular adhesion molecule-1 (ICAM-1, activation marker) and tissue factor (TF, inflammation marker) expressed on EC surface using immunofluorescence technique. Meanwhile, the peak WSS at the stenosis throat increased the TF expression.


Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

2990 руб
Бесплатная доставка


Английский язык для медиков: конспект лекций

Myeloid, or blood cell-forming tissue, is found in the bone marrow and provides the stem cells that develop into erythrocytes, granulocytes, agranulo-cytes, and platelets. Red marrow is characterized by active hematopo-iesis; yellow bone marrow is inactive and contains mostly fat cells. In the human adult, hematopoiesis takes place in the mar row of the flat bones of the skull, ribs and sternum, the vertebral column, the pelvis, and the proximal ends of some long bones. Erythropoiesis is the process of RBC formation. Bone marrow stem cells (colony-forming units, CFUs) differentiate into proerythroblasts under the influence of the glycoprotein erythropoietin, which is produced by the kidney. Proerythroblast is a large basophilic cell containing a large spherical euchromatic nucleus with prominent nucleoli. Basophilic erythroblast is a strongly basophilic cell with nucleus that comprises approximately 75% of its mass. Numerous cytoplasmic polyribosomes, condensed chromatin, no visible nucleoli, and continued hemoglobin synthesis characteristics of this cell ...»

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Набор детской складной мебели "Познайка".
Комплект складной. Сиденье детского стульчика изготовлено из материала с водоотталкивающей пропиткой. Удобный механизм складывания и
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