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Molecular Dissection of the Clonal M1T1 Group A Streptococci. Integrating Genomics, Proteomics, and Bioinformatics Tools to Define the Unique Features of a Pandemic Flesh-Eating Bacterial Strain

Автор:   Ramy K.A.
мягкая обложка
164 страниц
2009 год
Издательство:   Книга по Требованию
Цена:
2766 руб
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Описание:The resurgence of the severe diseases was thus suspected to be a result of an unusual pathogenic potential inherent to the few reemerging strains. A particular strain of the group A streptococci (GAS), known as the M1T1 clone, has exhibited unusual epidemiology and virulence, and has been largely associated with the pandemic of invasive GAS infections worldwide. This book, based on my PhD dissertation, discusses unique features that may have endowed the global M1T1 clone with its unusual properties, and the genomic and evolutionary basis for its emergence and persistence. Among M1T1' s unique features are its ability to switch to a hypervirulent phenotype with a survival advantage in deep tissues; the acquisition and exchange of mosaic prophages that encode novel exotoxins; and the production of the potent DNase Sda1, which frees the bacteria from the leukocyte extracellular traps. M1T1 was among few GAS strains that have outnumbered other serotypes since the mid-1980s, and their increase in GAS populations coincided with the resurgence of invasive and severe forms of streptococcal diseases, especially the streptococcal toxic shock syndrome (STSS) and necrotizing fasciitis (NF).


Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

2990 руб
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A short history of nearly everything

With the fossil record so unhelpful, scientists have turned increasingly to genetic studies, in particular the part known as mitochondrial DNA. Mitochondrial DNA was only discovered in 1964, but by the 1980s some ingenious souls at the University of California at Berkeley had realized that it has two features that lend it a particular convenience as a kind of molecular clock: it is passed on only through the female line, so it doesnБЂ™t become scrambled with paternal DNA with each new generation, and it mutates about twenty times faster than normal nuclear DNA, making it easier to detect and follow genetic patterns over time. By tracking the rates of mutation they could work out the genetic history and relationships of whole groups of people. In 1987, the Berkeley team, led by the late Allan Wilson, did an analysis of mitochondrial DNA from 147 individuals and declared that the rise of anatomically modern humans occurred in Africa within the last 140,000 years and that БЂњall present-day humans are descended from that population.БЂ« It was a serious blow to the multiregionalists ...»

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Шторка антимоскитная, бежевая.
Размеры: 100х220 см. Препятствует проникновению насекомых. Не нарушает естественную циркуляцию воздуха. Подходит для любых типов дверных
352 руб
Раздел: Сетки противомоскитные
Трос буксировочный "Stels", 10 тонн, 2 крюка (сумка на молнии).
Тросы буксировочные изготовлены из морозоустойчивого авиационного капрона. Не подвержены воздействию окружающей среды (резкому изменению
388 руб
Раздел: Буксировочные тросы
Беговел "Funny Wheels Basic" (цвет: голубой).
Беговел - это современный аналог детского велосипеда без педалей для самых маленьких любителей спорта. Удобный и простой в
2550 руб
Раздел: Беговелы


Biogeochemistry of the II.A group elements in a forested catchment. Biogeochemical cycles of the II.A group elements in a catchment covered with mixed forest in the central Czech Republic
The study of anthropogenic effects on II. A group elements was performed by means of a small catchment study at a strongly impacted part of Europe, in the central Czech Republic.
          1994 руб             2009 год          120 стр.          мягкая обложка

Irreducible Characters of the Special Linear Group. Over the Integers Modulo Prime Powers
Clifford Theory is then used to find the irreducible character of interest.
          2005 руб             2010 год          88 стр.          мягкая обложка

The third-chromosome group of mutant characters of Drosophila melanogaster
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An Introduction To The Theory Of Groups Of Finite Order
          2 руб             248 стр.          мягкая обложка

The Fibonacci Length of Groups and a Permutational Property of Semigroups Combinatorial Results on the Finite Presented Groups and Semigroups.
In this book we will consider two topics of the algebraic structures which concern the properties of finitely presented groups and semigroups.
          1875 руб             2011 год          80 стр.          мягкая обложка

The Memoirs of Catherine the Great
This definitive new translation from the French is scrupulously faithful to her words and is the first for which translators have consulted original manuscripts written in Catherine’s own hand.
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The Tainted Relic
Several decades later, the Cross turns up in the possession of a dealer, robbed and murdered en route to Glastonbury. It was July, 1100. Jerusalem lies ransacked.
          372 руб             2006 год          512 стр.          мягкая обложка

Estracts from address of department commander Samuel S. Burdett, at the 15th annual encampment of the Department of the Potomac, Grand Army of the Republic, ... at Washingington, D.C., January 30, 1883
          1424 руб             2011 год          мягкая обложка

The Sacred Stone
But treachery, discord and violent death follow for all who seek to possess it. At first, the mysterious ' sky-stone' seems to bring good luck. 1067. In the desolate wastes of Greenland, a band of hunters stumble across a strangely-shaped stone which has fallen from the sky.
          313 руб             2011 год          448 стр.          мягкая обложка

The Reading Group
Susan is the self-elected mother of the group but ironically she' s facing the terror of a future without her mother. And finally Clare is a woman consumed by love for the children she is longing - but unable - to have. A New Reading Group. Over the coming year their lives will intertwine in surprising ways. Loves are lost, hearts are broken and worlds are turned upside down, but through it all they have the Reading Group. Where the stories end, real life begins. And Polly is the epitome of a successful single mum, until a marriage proposal and an unexpected pregnancy threaten to derail her. A New Year. Five women gather for their first ever Reading Group; each is uncertain, clasping her expectations and fears close to her chest. A New Page. Harriet and Nicole are best friends who find themselves - in different ways - trapped in loveless marriages.
          864 руб             2010 год          576 стр.          мягкая обложка

Development of the Iteration Algorithm Making a Grouped-Data Frequency Table.
The first interest was to evaluate how accurate the iteration algorithm is as a process.
          3188 руб             2009 год          292 стр.          мягкая обложка

Cellular, Molecular and Biochemical Mechanisms The Pathophysiology of Sickle Cell Disease.
These microvascular responses are crucial to the initiation and progression of vasoocclusive crises, the disease’s critical pathophysiological event that leads to pain crises, organ injury and early mortality.
          2766 руб             2009 год          192 стр.          мягкая обложка

p-groups of maximal class. Periodic structures in the graph associated with p-groups of maximal class
He gives a survey on the known structure of these groups and he proved two types of periodic patterns in the associated coclass graph.
          3212 руб             2009 год          132 стр.          мягкая обложка

L-Amino Acid Sensing by the Calcium Sensing Receptor. Molecular and Functional Analysis
Furthermore, the roles of putative amino acid binding site residues in the Venus Fly Trap domain were investigated using conservative and semi-conservative mutations of the following residues:
          2781 руб             2009 год          196 стр.          мягкая обложка

An Analysis of the BMW Group The Internationalisation of EDI in the Automotive Industry.
In recent years the automotive industry has experienced significant changes due to the globalisation of its value chain.
          2413 руб             2008 год          132 стр.          мягкая обложка

Small Meat Lockers Working Group. A Participatory Action Research Project to Revitalize the Decentralized Meatpacking Sector in Iowa
This book discusses the discovered five critical needs areas of small-scale meat processors:
          2005 руб             2010 год          52 стр.          мягкая обложка

The Lower Algebraic K-Theory of Braid Groups on S2 and RP2. Braids
We illustrate the defnitions with specific examples used later on to discuss the proof of the main results of this work.
          2005 руб             2008 год          72 стр.          мягкая обложка

Molecular Dynamics Simulations of the Neu Transmembrane Domain. Physical Characterization of Native and Mutated Neu in a Membrane Environment
Key mutations at a specific location in the transmembrane domain (TMD) of the neu protein have been demonstrated to result in permanent dimerization of mutated pairs, and are simultaneously associated with the formation of cancerous tumors.
          2781 руб             2009 год          196 стр.          мягкая обложка

Algorithmic Problems in the Braid Group. Theory and Applications
We offer a quick solution to the generalized word problem in braid groups, in the special case of cyclic subgroups.
          2005 руб             2009 год          84 стр.          мягкая обложка

Residential Segregation, Religious Affiliation and Ethnicity. The geographies of Dundee's and Glasgow's Indian and Pakistani Faith Groups
This book details results from Sarah-Anne Munoz' s doctoral research that investigated whether religion is important in explaining the residential patterning of ethnic minority groups by considering the Indian and Pakistani populations of two Scottish cities. The book presents both quantitative and qualitative understandings of ethnic-faith geographies, as well as utilising a unique set of geographical boundaries to make accurate comparisons between different census years. This assesses the role of religious affiliation in the production and evolution of ethnic residential segregation. Using qualitative methods it also investigates the role of religion in the construction of place-based identities and notions of community. Studies of immigrant groups within the UK have long been couched in terms of nation-based ethnic classifications. Yet the religious affiliation of such groups is increasingly prominent within societal and policy discourse. Previous studies have examined the spatial distribution of ethnic groups or religious affiliation but rarely have the interactions between ethnicity and faith been considered.
          3231 руб             2009 год          308 стр.          мягкая обложка

Applying Group Technology to reduce the setup time of production. and using Film as an example
To survive, some of the factories tried to cut costs by improving the efficiencies of production while others moved to the lower labor cost countries.
          2005 руб             2010 год          76 стр.          мягкая обложка

MOLECULAR ANALYSIS OF EPHEDRA SPECIES FOUND IN PAKISTAN. USE OF RAPD MARKERS TO RESOLVE SPECIES ANOMALIES IN THE GENUS EPHEDRA
Quantity and quality of chemicals present in the genus vary species to species.
          2005 руб             2010 год          56 стр.          мягкая обложка

Student teachers and teacher students. Group work and leadership in the teaching practicum
This book provides an analysis of group work in the teaching practicum in initial English teacher education.
          2781 руб             2010 год          164 стр.          мягкая обложка

Sustainability - Impact on Corporate Value. At the Practical Example of the HVB Group
Sustainability is en vogue!
          2005 руб             2010 год          104 стр.          мягкая обложка

Molecular Characterisation of the Ribgrass Mosaic Virus - Impatiens. The Use of Mutation Constructs to Evaluate Virulence and Virus Accumulation on Nicotiana benthamiana and N. tabacum
Accordingly, all three mutants show both lower virus accumulation levels and lesser symptom characteristics.
          2005 руб             2008 год          112 стр.          мягкая обложка

VIRTUAL TEAM EFFICACY IN INFORMATION SYSTEMS PROJECT MANAGEMENT TEAMS. TESTING THE INFLUENCE OF COLLECTIVE EFFICACY BELIEFS ON GROUP LEVEL PERFORMANCE METRICS
While numerous theoretical frameworks have been employed by researchers interested in the performance of virtual teams, one framework that shows particular promise is social cognitive theory (SCT).
          2781 руб             2010 год          200 стр.          мягкая обложка

An investigation into the worldview of a selected group of Norwegian Army Cadets from a complexity and leadership perspective Complexity and Leadership.
The empirical framework of this book is the Norwegian Armed Forces where the Cadets at the Norwegian Military Academy, branch of Army, are the subject of research.
          2781 руб             2010 год          196 стр.          мягкая обложка

The Case of Farmer Research Groups In Adama Woreda, Ethiopia Farmers Participation in Farmers' Participatory Research.
So that Farmers' participation in agricultural research has not gained momentum at the local, regional and international levels. This book is first of its kind in seeing the determinants and patterns of farmers' participation in agricultural research.
          2005 руб             2010 год          112 стр.          мягкая обложка

Group Interaction in the ‘Outdoor Classroom':. the Process of Learning in Outdoor Education
The findings show that the concept of team building is central to the philosophy of the outdoor centre and of its staff.
          3231 руб             2010 год          364 стр.          мягкая обложка

Political Groups of the European Parliament
Provided those criteria are met, MEPs can theoretically create any Group they like.
          1588 руб             2010 год          108 стр.          мягкая обложка

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