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Clinical limitations, safety issues and prospects Oncolytic Viruses Cancer Therapy.

Автор:   Marc Z.
мягкая обложка
172 страниц
2009 год
Издательство:   Книга по Требованию
2766 руб
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Описание:However, as their therapeutic efficacy in clinical trials is still not optimal, strategies are evaluated that could further enhance the oncolytic potential of conditionally replicating viruses. An overview is given of the general mechanisms and genetic modifications by which oncolytic viruses achieve tumor cell-specific replication and antitumor efficacy. Wild-type viruses with intrinsic oncolytic capacity in human includes DNA viruses like some autonomous parvoviruses and many RNA viruses. However, still several hurdles regarding clinical limitations and safety issues should be overcome before this mode of therapy can become of clinical relevance. It includes limited virus spread in tumor masses, stability of virus in the blood, trapping within the liver sinusoids, transendothelial transfer, and/or vector diffusion of viral particles to tumor cells, limited tumor transduction, immune-mediated inactivation or destruction of the virus. Recent advances in molecular biology have allowed the design of several genetically modified viruses, such as adenovirus and herpes simplex virus that specifically replicate in, and kill tumor cells.

Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

2990 руб
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The Language of the Genes

The epidemic of allergy and asthma. Nature 402: supp B2-B39. Owen, M. J. and Cardno, A.G. 1999. Psychiatric genetics: progress, problems and potential. Lancet 354 suppl 1: n—14. O'Donovan, M. C. and Owen, M. J. 1999. Candidate-gene association studies of schizophrenia. American Journal of Human Genetics 65: 587–592. CHAPTER SIX: BEHIND THE SCREEN Holtzman, N. and Shapiro, D. 1998. Genetic testing and public policy. British Medical Journal 316: 852–856. Kinmonth, A. L., et al. 1998. The new genetics: implications for clinical services in Britain and the United States. British Medical Journal 316: 767–770. Krynetsti, E.Y. and Evans, W. E. 1998. Pharmacogenetics of cancer therapy: getting personal. American Journal of Human Genetics 63: ir-16. Lenaghan, J. 1998. Brave New NHS? The Impact of the New Genetics on the Health Service Institute for Public Policy Research, London. Mao, X., j 998. Chinese geneticists' views of ethical issues in genetic testing and screening: evidence for eugenics in China. American Journal of Human Genetics. 63: 688–695. Martcau, T. and Croyle, R. T. 1998 ...»

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