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Microparticle Formation by Spray-Freeze-Drying. The Influence of Atomization Conditions on Protein Secondary and Tertiary Structure

Автор:   Sebastian V.
мягкая обложка
188 страниц
2010 год
Издательство:   Книга по Требованию
3618 руб
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Описание:The process is analyzed after a) atomization b) atomization, freezing and thawing and c) the complete SFD process. A thorough comparison of the utilized ultrasound nozzles (including particle size distribution, temperatures and cavitation effects) is performed in the third part of this thesis. In the fourth and last part, different formulations containing a mixture of alpha-chymotrypsin and various excipients are evaluated for their stability. As the process consists of various unit operations, the stability of labile APIs, such as proteins, can be serverly impaired. However, quantification of protein secondary structure by FTIR spectroscopy can show poor reproducibility. This thesis deals with the preparation microparticles by spray-freeze-drying (SFD). The second part investigates the influence of atomization conditions on protein secondary and tertiary structure as well as residual enzyme activity during SFD. The secondary structure of a protein is known to be directly linked to its overall stability. Therefore, the first part of this thesis covers the development of a new FTIR method for objective and fast determination of protein secondary structure.

Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

2990 руб
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Большая Советская Энциклопедия (БА)

Выступает против утверждения Ж. Б. Сэя об автоматическом саморазвитии рынков сбыта. Б. исследовал также движение зарплаты и рост населения в условиях развитого капитализма.   Соч.: Observations on the circumstances which influence the condition of the labouring classes of society, L., 1817.   Лит.: Маркс К., Теории прибавочной стоимости (IV том «Капитала»), ч. 2, гл. 18, ч. 3, гл. 22, Маркс К. и Энгельс Ф., Соч., 2 изд., т. 26, ч. II и III. Бартош Милан Ба'ртош (Bartoš) Милан (р. 1901), югославский юрист, специалист по международному праву, профессор Белградского университета, вице-президент Сербской академии наук и искусств, член Комиссии международного права ООН и Постоянной палаты третейского суда в Гааге. Основные труды в области международного публичного и международного частного права, в том числе «Право международной торговли» (1927), «Международное частное право» (1932), «Основы международного права» (1936), «Правовое положение иностранцев» (1947), «Вексельное и чековое право» (1953), «Правовое положение иностранных предприятий в Югославии» (1956), а также курс международного права (1954—58) ...»

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