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Органическая химия Органическая химия

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Parameters of intrathymic regulatory T cell differentiation. Thymic Treg development does not require a dedicated antigen-presenting cell type but is under T cell-intrinsic control

Автор:   Gerald W.
мягкая обложка
80 страниц
2009 год
Издательство:   Книга по Требованию
Цена:
2359 руб
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Описание:We propose that the intrinsically high predisposition of immature thymocytes to Treg development may contribute to the predominantly thymic origin of the Treg repertoire. The majority of regulatory T cells (Tregs) are believed to be of thymic origin. The underlying instructive stimulus, however, does not require unique features of a dedicated APC and can be delivered by hematopoietic as well as epithelial thymic stromal cells. It has been hypothesized that this may result from unique intrathymic environmental cues, possibly requiring a dedicated antigen presenting cell (APC). In support of quantitative but not qualitative features of external cues being critical, thymic epithelial cells as well as different thymic dendritic cell (DC)-subtypes efficiently induced Treg development of immature thymocytes. We found that upon exposure of monoclonal T cells of sequential developmental stages to a thymic microenvironment expressing cognate antigen, the efficiency of Treg induction inversely correlated with progressive maturation. However, T cell intrinsic developmental regulation of the susceptibility to Treg differentiation remains a mutually non-exclusive scenario.


Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

2990 руб
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Embedded Linux Primer: A Practical, Real-World Approach

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