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Impact of single strand annealing on DNA repair in mammalian cells. A component of the double strand break repair network

Автор:   Wael Y.M.
мягкая обложка
108 страниц
2009 год
Издательство:   Книга по Требованию
Цена:
2359 руб
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Описание:In the current work we propose a model for a functional hierarchy for DSB repair network in mammalian cells. If one of central repair proteins is missing or the damage signalling is disturbed, these repair pathways crosstalk with each other in order to maintain the survival even at the expense of repair fidelity. In order to avoid the deleterious effect of double strand breaks (DSBs), mammalian cells have evolved three efficient repair pathways namely; nonhomologous endjoining (NHEJ), gene conversion(GC)and single strand annealing (SSA). According to this hierarchy, high-fidelity NHEJ dominates and suppresses the other two repair pathways. These pathways differ not only in the underlying mechsnism but also in the fidelity of the repair. Whereas GC mostly ensures accurate repair, neither NHEJ nor SSA does. As the DNA damage signalling is impaired in most tumours, assessing the crosstalk and the hierarchy between repair pathways in tumour cells would be of most important in the future. The misrepair of DSBs may induce genetic alterations with consequences such as cell death or cancer. GC also dominates over and suppresses the most deleterious SSA repair pathway.


Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

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The Rise and Fall of the Third Chimpanzee. Evolution and Human Life

Kirkwood, The nature and causes of ageing', pp. 193–206 in a book edited by D. Evered and J. Whelan, Research and the Ageing Population (John Wiley, Chichester, 1988). Two books exemplifying the physiological (proximate-cause) approach to aging are by R.L. Walford, The Immunologic Theory of Aging (Munksgaard, Copenhagen, 1969), and MacFarlane Burnett, Intrinsic Mutagenesis: A Genetic Approach to Ageing (John Wiley, New York, 1974). Some papers exemplifying the literature on biological repair and turnover are by R.W. Young, 'Biological renewal: applications to the eye', Transactions of the Opthalmological Societies of the United Kingdom 102, pp. 42–75 (1982); A. Bernstein et al, 'Genetic damage, mutation, and the evolution of sex', Science 229, pp. 1277-81 (1985); J.F. Dice, 'Molecular determinants of protein-half lives in eukaryotic cells', Federation of American Societies for Experimental Biology journal 1, pp. 349-57 (1987); P.C. Hanawalt, 'On the role of DNA damage and repair processes in aging: evidence for and against', pp. 183-98 in a book edited by H.R ...»

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