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Total Synthesis of Callipeltin E and Towards Papuamide B. Syntheses of Anti-HIV

јвтор:   SELCUK C.
м€гка€ обложка
128 страниц
2008 год
»здательство:    нига по “ребованию
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2413 руб
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ќписание:The novel structural features and diverse biological effects of these peptides metabolites have generated considerable interest among synthetic chemistry groups. In this book, discovery of the lanthanide catalyzed transamidation of Fmoc protected lactams, solid-phase synthesis and configurational reassignment of Callipeltin E, synthesis of N-Fmoc- (2S,3S,4R)-3,4-dimethylglutamine and an efficient method for the on-resin synthesis and macrocylization of a simplified Papuamide B model system are summarized. Callipeltins and Papuamides -novel families of cyclic depsipeptides- were shown to possess potent anti-HIV activity as well as cytotoxicity against several multidrug resistant cancer cell lines.


Orthomol Immun Junior —ила иммунитета на страже ¬ашего ребенка Orthomol Immun Junior —ила иммунитета на страже ¬ашего ребенка

2990 руб
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Bad Science

When you read a dramatic claim like HolfordЅАЩs, you might assume itЅАЩs based on some kind of study, perhaps where people with AIDS were given vitamin C. ThereЅАЩs a little superscript ЅАШ23ЅАЩ, referring you to a paper by someone called Jariwalla. With bated breath I grabbed a copy of this paper online. The first thing I noticed was that this paper does not mention ЅАШAZTЅАЩ. It does not compare AZT with vitamin C. Nor does it involve any human beings: itЅАЩs a laboratory study, looking at some cells in a dish. Some vitamin C was squirted onto these cells, and a few complicated things were measured, like ЅАШgiant cell syncytia formationЅАЩ, which changed when there was lots of vitamin C swimming around. All well and good, but this laboratory-bench finding very clearly does not support the rather dramatic assertion that ЅАШAZT, the first prescribable anti-HIV drug, is potentially harmful, and proving less effective than vitamin C.ЅАЩ In fact, it seems this is yet another example of that credulous extrapolation from preliminary laboratory data to clinical claim in real human beings that we have come to recognise as a hallmark of the ЅАШnutritionistЅАЩ ...»

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ћаркеры дл€ написани€ и маркировки текста на белых досках. —тираетс€ сухой губкой почти со всех плотных поверхностей, например, эмали,
592 руб
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1350 руб
–аздел:  аталки
ѕеленка ѕапитто фланелева€ (3 штуки, 120x75 см).
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466 руб
–аздел: ѕелЄнки


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A modeler creates effective models, representing useful software artifacts, in a modelling domain.
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