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The many Faces of the SOCS Box. Regulation of SOCS Proteins SOCS Proteins and Cytokine Signalling:

Автор:   Julie P.
мягкая обложка
212 страниц
2008 год
Издательство:   Книга по Требованию
3231 руб
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Описание:Important advances have been made in understanding their mode of action. Undoubtedly, knowledge of how SOCS proteins are regulated may lead to development of potent therapeutic options in the treatment of several disorders. This work should help to further understand the mechanisms underlying SOCS actions. However, unresolved issues include the involvement of SOCS in the modulation of specific pathways and the mechanisms controlling stability and regulation of these proteins. SOCS proteins are regulators of various signal transduction cascades that are essential to normal physiology. In the second part of this book novel roles for the SOCS box domain in the cross- regulation of other SOCS proteins and in substrate binding are reported. The hormone leptin emerged as a key player in body weight regulation but it also has peripheral effects on diverse body functions. The importance of this is underscored by the contribution of inappropriately regulated SOCS activity to several pathologies including cancer and inflammatory diseases. This work provides further insights in the role of SOCS proteins in different signalling pathways such as leptin signal transduction.

Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

2990 руб
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Why is Sex Fun?: the evolution of human sexuality

Poor nutrition may leave you with a scrawny body and disfigured face, but it rarely causes your pubic hair to fall out. Even weak ugly men and skinny ugly women sport axillary hair. Men's beards, body hair, and low-pitched voices as signals of adolescence, and men's and women's hair whitening as a signal of age, seem equally devoid of inner meaning. Like the red spot on a gull's bill and many other animal signals, these human signals are cheap and wholly arbitrary-many other signals can be imagined that would serve equally well. Is there any human signal that exemplifies the operation of Fisher's runaway selection model or Zahavi's handicap principle? At first, we seem devoid of exaggerated signaling structures comparable to a widowbird's sixteen-inch tail. On reflection, however, I wonder whether we actually do sport one such structure: a man's penis. One might object that it serves a nonsignaling function and is nothing more than well-designed reproductive machinery. However, that is not a serious objection to my speculation: we have already seen that women's breasts simultaneously constitute signals and reproductive machinery ...»

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Карандаши цветные "Progresso", 12 цветов.
Бездревесные цветные карандаши "Progresso" имеют прочное лаковое покрытие, легко затачиваются с помощью обычной карандашной
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Трехколесный велосипед Funny Jaguar Lexus Racer Trike Air (цвет: бронза).
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4200 руб
Раздел: Трехколесные
Набор детской мебели "Растем вместе" (цвет: орех).
Качественная детская мебель всегда отличается от взрослой, так как производится с учетом строения тела малыша и того, что он быстро
4541 руб
Раздел: Наборы детской мебели

A Method to Integrate Protein Interaction and Gene Expression Data Analysis of Signalling Events.
The proposed method is able to cope with contradicting data and pays attention to the importance of feedback loops for differentiation processes.
          2005 руб             2008 год          104 стр.          мягкая обложка

Disulfide/Dithiol redox titrations of proteins. Regulation of protein expression
AppA and PpsR are present in R. sphaeroides regulate gene expression in response to oxygen.
          1994 руб             2009 год          76 стр.          мягкая обложка

Interleukin-17 is a key cytokine in first-line defence of the skin
Communication between cells as a prerequisite for life of multicellular organisms is achieved mostly by solvent mediators like hormons, neurotransmitters, cytokines and chemokines.
          2359 руб             2010 год          92 стр.          мягкая обложка

Essential proteins of parasitic nematodes:. Proteomic analysis of excretory/secretory proteins from parasitic and free-living stages of Strongyloides ratti
The high genetic similarity then allows to draw parallels between the human parasite and other Strongylid nematodes.
          3984 руб             2009 год          204 стр.          мягкая обложка

Interactions between Viral and Motor Proteins - a Gene Therapy Vector for Spinal Cord Disease? Retrograde Cellular Transport of Herpes Simplex Virus.
To study retrograde transport of HSV-1, capsid and tegument proteins were tested for interactions with the motor cytoplasmic dynein, using a yeast two-hybrid system and in vitro pull down assays.
          2781 руб             2008 год          180 стр.          мягкая обложка

Data Analysis for Mass Spectrometry-Based Proteomics. Novel Data Analysis Methods and Algorithms for Identification of Peptides and Proteins by Use of Tandem Mass Spectrometry
Three different scoring algorithms have been developed to identify and characterize proteins and peptides by use of tandem mass spectrometry data.
          3231 руб             2008 год          236 стр.          мягкая обложка

A Proteomic Approach for Bordetella Pertussis. Identification of the New Immunogenic Proteins of Bordetella pertussis, the Causative Agent of Whooping Cough, by Immunoproteomics
The term proteome, in analogy to the term genome, was coined to describe the complete set of proteins that an organism has produced under a defined set of conditions.
          2005 руб             2009 год          120 стр.          мягкая обложка

Accruals: Signalling or misleading?. Evidence from New Zealand
Few studies however, argue that managers can also use accruals to improve the value relevance of reported earnings to help investors better assess the firm’s operating performance.
          2005 руб             2009 год          108 стр.          мягкая обложка

Quality Characteristics of Common Carp Surimi. With Emphasis on Role of Sarcoplasmic Proteins on Surimi Gel Network
The reason for choosing common carp for this project was because carp is common, little exploited, and has a reputation in Australia as a poor quality seafood source, therefore, a transformed product such as surimi has a better chance of acceptance in the market.
          2781 руб             2010 год          164 стр.          мягкая обложка

Stress Biochemistry Heat Shock Proteins Expression under Stress.
Abiotic stimuli, such as heat, cold, water deficit, heavy metals, ozone, UV radiation and ? -irradiation effects the synthesis and accumulation of HSPs.
          2005 руб             2010 год          88 стр.          мягкая обложка

Token (Railway Signalling)
In railway signalling, a token is a physical object which a locomotive driver is required to have or see before entering onto a particular section of single track.
          1840 руб             2010 год          140 стр.          мягкая обложка

Synchronous Signalling in Navigation
          596 руб             2010 год          мягкая обложка

Cytokine gene polymorphisms in the pathogenesis of chronic gastritis. Chronic gastritis
H pylori is seen in about 56. 6 % of the cases of gastritis.
          2623 руб             2010 год          164 стр.          мягкая обложка

VDR mediated calcitriol signalling related to ?6?1- and ?6?4-Integrin. Immunoprecipitation using keratinocytes
Their proliferation and differentiation is regulated by 1,25-dihydroxyvitaminD3, that also influences the mRNA expression of integrins especially, heterodimers between different integrin types. Integrin ? 6 is able to form heterodimers in keratinocytes with either ? 1 or ? 4. Using real-time expriments, the influence of 1,25-dihydroxyvitaminD3 on integrin gene-expression in human HaCaTs was studied in vitro.
          2277 руб             2010 год          124 стр.          мягкая обложка

Imidazoline Receptors in Insulin Signaling and Metabolic Regulation. Molecular Basis for I1-imidazoline Binding and Cell Signaling and the Mechanisms Linking this Signaling Protein to Regulation Glucose Metabolism
These results implicate adipose tissue as a locus of insulin resistance in this model of metabolic syndrome.
          3231 руб             2008 год          212 стр.          мягкая обложка

FAST AND CHEAP PROTEIN PURIFICATION. Economical alternatives to conventional chromatography-based recombinant protein purification
The two systems have been successfully used at laboratory scale to purify more than a dozen proteins varying in size, complexity and activity, demonstrating the proof of principle, high purity and yield attainable.
          2382 руб             2009 год          136 стр.          мягкая обложка

Exploring the relatively new field of Bioinorganic Chemistry, this book contains an initial approach towards the study of different chemical interactions of platinum(II) and palladium (II)ions with essential biological substrates such as nucleobases and aminoacids, the basic components of DNA/RNA and proteins respectively.
          3188 руб             2009 год          248 стр.          мягкая обложка

Schlussleisten (Zonulae occludentes) und biochemisch verwandte Strukturen. Tight Junction-Proteine und -Funktionen in mehrschichtigen Epithelien, mit besonderer Beruecksichtigung der Plattenepithelmetaplasie
Diese Arbeit beschaeftigt sich mit der Frage, welche TJ-Proteine in bestimmten TJ-Strukturen oder in sog.
          3188 руб             2008 год          224 стр.          мягкая обложка

Expression, purification and cellular uptake of a S100A4 protein. an agent promoting metastasis
A recombinant S100A4 protein was produced in Pichia pastoris (Pichia).
          2382 руб             2009 год          152 стр.          мягкая обложка

Functional genomic of receptor kinases in Solanum chacoense. mechanistic of plant receptor kinase signaling
The first chapter details the mechanistic of plant receptor kinase structure and activation and details the roles of each domain and their properties and compares it with what is known of receptor animal kinase activation.
          3212 руб             2009 год          220 стр.          мягкая обложка

Design and Verilog-A Modeling of Phase-Locked Loop Based Clock and Data Recovery Integrated Circuit for 10 Gb/s Intra/Inter Chip Communications in SoC Design and Modeling of PLL Based CDR for Inter Chip Communications.
In order to verify the accuracy of the proposed quarter-rate concept, a clockless asynchronous serial link incorporating the proposed concept and communicating two chips at 10 Gb/s has been modeled at gate level using the Verilog-A language and time-domain simulated.
          2400 руб             2009 год          148 стр.          мягкая обложка

Dynamic protein assemblies in homologous recombination. studied by single-molecule techniques
With the use of single-molecule techniques like magnetic tweezers and atomic force microscopy, the complex mechanism of the DNA repair pathway of homologous recombination is slowly unraveled.
          3212 руб             2009 год          232 стр.          мягкая обложка

For High Level System Design SystemC-A: Analogue and Mixed-Signal Language.
In this book a novel methodology has developed that enables the extension of SystemC to the analogue domain and allows simulations of mixed-signal and mixed-domain systems on arbitrary levels of abstraction.
          3212 руб             2009 год          252 стр.          мягкая обложка

Motorische Inhibition bei Patienten mit einer Zwangsstoerung. Eine Untersuchung mit dem Stopp-Signal-Paradigma
Bei Verwendung einfacher, geometrischer Figuren als Reaktionszeitsignal fand sich keine Evidenz fuer ein inhibitorisches Defizit der Patientengruppe.
          3984 руб             2010 год          292 стр.          мягкая обложка

Compensation of the Systematic Angle Error Caused by Air Gap Variations Using Decision Feedback Equalizer Approach Adaptive Predictive Signal Processing for Integrated Sensors.
This thesis presents a solution for increasing the angle accuracy of a magnetic sensing arrangement by using the processing power available on today' s integrated sensors. A digital filter with adaptive and predictive algorithms estimates and compensates for systematic errors by using a simplified physical model of the arrangement. The physical parameter values of the arrangement are known after adaption is completed. With the proposed filter structure the accuracy of the sensing arrangement can be defined by chip design. High integration densities of new semiconductor technologies allow the integration of complex digital signal processing onto a small silicon area. The main disadvantage of using the magnetic technique is its limited angle accuracy, which is caused by a systematic error of the sensing arrangement. Due to their high degree of robustness and low production costs, magnetic field sensors are the preferred types of sensors for such applications. Due to new technologies, high processing power is also available on the small chip area of integrated sensors. Precise speed and angle measurements of rotating shafts are very important in automotive engineering applications.
          2359 руб             2009 год          116 стр.          мягкая обложка

Protein-Phosphatase-Inhibitor-1 in der menschlichen Herzinsuffizienz. Ist der Inhibitor-1 in insuffizienten menschlichen Herzen reguliert und hat Calcineurin im Herzen einen Einfluss auf dessen Phosphorylierung?
Uber Calcineurin koennte Inhibitor-1 einen potentiell wichtigen cross talk zwischen cAMP- und Ca2+-Signalwege im Herzen vermitteln.
          3212 руб             2009 год          148 стр.          мягкая обложка

Caveolae, Lipid Rafts and Clathrin-coated Pits - Impact of Endocytic Pathways on BMP Signaling Localization of BMP Receptors in Specific Plasma Membrane Microdomains.
BMPs are members of the TGF-? superfamily and are involved in the regulation of proliferation, differentiation, chemotaxis and apoptosis.
          2400 руб             2008 год          156 стр.          мягкая обложка

Number. A New Method for Estimating the Direction-of-Arrival and Determining the Numbers of Coherent Impinging Signals
Besides, we can find out the number of signals by counting the non-zero eigenvalues of the covariance matrix of this new matrix.
          2005 руб             2008 год          64 стр.          мягкая обложка

New--Potentially Irreversible--Kinase Inhibitors, Computational Modeling of the Signaling Cascade, and the Effect of DiRas3 on RAF Signaling Pathway, Modulation and Modeling. RAF Kinases:
The development of specific irreversible kinase inhibitors is a rewarding but difficult aim.
          2005 руб             2008 год          96 стр.          мягкая обложка

Cardiac Evaluation of the Developmental Origins of Adult Cardiovascular Diseases. Insulin-like Growth Factor Binding Protein-1 and the Developmental Origins of Adult Cardiovascular Diseases
IGFs are essential regulators of fetal growth.
          2413 руб             2008 год          124 стр.          мягкая обложка


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