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Antisense-mediated exon skipping for Duchenne muscular dystrophy. Development of an antisense-mediated exon skipping therapy for Duchenne muscular dystrophy Making sense out of nonsense

Автор:   Annemieke A.
мягкая обложка
120 страниц
2009 год
Издательство:   Книга по Требованию
2005 руб
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Описание:Duchenne muscular dystrophy (DMD) is a severe, progressive muscle wasting disease for which there is currently no cure. It provides an overview of potential therapies for Duchenne muscular dystrophy and describes how antisense-mediated modulation of splicing can be used for other therapeutic and research purposes. This thesis focuses on the development of a promising new therapy, so called antisense-mediated exon skipping, that aims to restore the disrupted dystrophin reading frame to allow generation of internally deleted, but partly functional dystrophin proteins, as found in the less severe Becker muscular dystrophy. The thesis describes the DMD gene, the dystrophin protein, diseases associated with mutations in the DMD gene and animal models. The disease is caused by mutations in the DMD gene that completely abolish the function of the protein dystrophin. Finally it gives a detailed overview of the rationale and the development of the exon skipping therapy for Duchenne muscular dystrophy.

Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

2990 руб
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The Black Swan: The Impact of the Highly Improbable

I later saw the exact same illusion of understanding in business success and the financial markets. History Does Not Crawl, It Jumps Later, upon replaying the wartime events in my memory as I formulated my ideas on the perception of random events, I developed the governing impression that our minds are wonderful explanation machines, capable of making sense out of almost anything, capable of mounting explanations for all manner of phenomena, and generally incapable of accepting the idea of unpredictability. These events were unexplainable, but intelligent people thought they were capable of providing convincing explanations for themБЂ”after the fact. Furthermore, the more intelligent the person, the better sounding the explanation. WhatБЂ™s more worrisome is that all these beliefs and accounts appeared to be logically coherent and devoid of inconsistencies. So I left the place called Lebanon as a teenager, but, since a large number of my relatives and friends remained there, I kept coming back to visit, especially during the hostilities ...»

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512 руб
Раздел: Игры логические

Functioning and Resilience in Families with Children with Duchenne Muscular Dystrophy Family resilience and functioning in child with DMD.
Parents, patients or teachers in any other discipline or in caring of any other chronic disease will pick up new ideas to build family relationship and to use resources for improving your quality of life by reading this book.
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Antisense RNA-mediated gene silencing in fission yeast. Initial evidence of RNAi in a yeast model
Finally, a unique overexpression screen identified four novel factors that specifically enhanced antisense RNA-mediated gene silencing.
          3212 руб             2009 год          232 стр.          мягкая обложка

Regions of E. coli RNA polymerase required for ? ? Q interaction with E. coli RNA polymerase for antitermination. Q-mediated antitermination in binding and function
Q antitermination within the potential ? Phage ? Q protein is a transcriptional antiterminator that is required for late gene expression from the pR’ promoter when ? prophage decides to follow the lytic pathway. ? Q modifies Escherichia coli RNA polymerase (RNAP) at the early elongation stage. Once engaged, ? Q maintains itself as a subunit of the elongation complex throughout the elongation. Studies show that ? Q confers RNAP resistance to both intrinsic and ? -mediated terminators and less pausing.
          2744 руб             2009 год          176 стр.          мягкая обложка

N-Heterocyclic carbene complexes of transition metals. N-Heterocyclic carbenes and their application as ligands for transition metal mediated synthesis
An array of functionalised carbene precursors are prepared, each possessing a masked carbene in a 1,5 relationship to a chelating oxo-substituent.
          3212 руб             2009 год          384 стр.          мягкая обложка

Hegemony Mediated. The Roots of Militaristic Media Discourse in Turkey
The military as a strong social actor and militarist discourse as a component of national foundational myth in Turkey suggest a ground for examining the role of cultural factors in the media realm.
          2005 руб             2008 год          84 стр.          мягкая обложка

Computer-Mediated-Communication. in Pre-graduate Mathematics Courses
          2005 руб             2008 год          92 стр.          мягкая обложка

Advances in the investigation of protein adsorption. New sensing platforms based on nanoscopic devices for probing lipid membrane mediated interactions
This is the first experimental approach that combines successfully the lipid membranes with the concept of single particle LSPR sensing.
          2781 руб             2010 год          176 стр.          мягкая обложка

Electrophysiology in Action. The of Actions of General Anaesthetic Agent Propofol on Cardiac Ion Channels before and after Phosphorylation Mediated by B-Adrenoceptor Pathways
The effects of propofol on IK were reversible.
          2005 руб             2008 год          60 стр.          мягкая обложка

X-Linked Endothelial Corneal Dystrophy
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          1182 руб             2010 год          68 стр.          мягкая обложка

Physical education by muscular exercise
          598 руб             2011 год          мягкая обложка

Health by muscular gymnastics
          598 руб             2011 год          мягкая обложка

Myotonic Dystrophy
Myotonic dystrophy is a chronic, slowly progressing, highly variable inherited multisystemic disease.
          1332 руб             2010 год          84 стр.          мягкая обложка

Technology Mediated Learning for Teacher's Professional Development. Innovative ideas to improve In-Service Teacher Education
This book puts forward a pedagogical approach, namely, future innovative in-service teacher education in Europe.
          1891 руб             2010 год          76 стр.          мягкая обложка

VDR mediated calcitriol signalling related to ?6?1- and ?6?4-Integrin. Immunoprecipitation using keratinocytes
Their proliferation and differentiation is regulated by 1,25-dihydroxyvitaminD3, that also influences the mRNA expression of integrins especially, heterodimers between different integrin types. Integrin ? 6 is able to form heterodimers in keratinocytes with either ? 1 or ? 4. Using real-time expriments, the influence of 1,25-dihydroxyvitaminD3 on integrin gene-expression in human HaCaTs was studied in vitro.
          2277 руб             2010 год          124 стр.          мягкая обложка

Skipping Christmas
Luther and Nora Krank are fed up with the chaos of Christmas.
          555 руб             2010 год          256 стр.          мягкая обложка

A treatise on localized electrization, and its applications to pathology and therapeutics
          1145 руб             2011 год          мягкая обложка

The Mediator 3: Mean Spirits
So Suze is hardly surprised when a fatal car accident wreaks havoc on her perfect summer.
          463 руб             2005 год          208 стр.          мягкая обложка

Mean Spirits and Young Blood The Mediator:
She must use her mediating skills to guide these ghouls through the afterlife and stop them wreaking havoc in the present.
          634 руб             2010 год          448 стр.          мягкая обложка

Konfliktbewaeltigung durch Mediation in Gesundheits- und Pflegeberufen. Mediation als Instrument Konflikte in Pflegeteams zu loesen
Der kontinuierliche Versuch, Konflikte zu umgehen, kann eine erstarrte Kreativitaet und Angepasstheit zur Folge haben.
          1978 руб             2008 год          84 стр.          мягкая обложка

Aggression at work. Prevalence, mediating factors and consequences Bullying, nasty teasing and violence.
The three types of aggression at work seem to have much in common with regard to social climate at work, personal dispositions, the tendency of repeated exposure and the serious consequences on the victims’ health and well being.
          1994 руб             2009 год          88 стр.          мягкая обложка

Die Bedeutung der Kommunikation in der Mediation
Sein Wissen von Bedingungen, die die Kommunikation foerdern, ist unabdingbare Voraussetzung einer "guten" Mediation.
          2005 руб             2010 год          108 стр.          мягкая обложка

Stress and Coping among Professional Mediators:. attributes and competencies
Providing qualitative and quantitative evidence, the book has relevance for mediation trainers and practitioners, and for the organisations which employ them.
          3231 руб             2008 год          420 стр.          мягкая обложка

Play strategies used by siblings of children with autism spectrum disorders Sibling Mediation.
This book explores the systematic strategies used by typically developing children to facilitate social interaction for their sibling with an autism spectrum disorder (ASD).
          3231 руб             2009 год          224 стр.          мягкая обложка

How the psychology of risky choice, inherent bias and conflict resolution can inform and improve American Alternative Dispute Resolution Mastering Mediation: Conflict, Bias, Risk and Legal Negotiations.
First, it aims to identify and address disputants’ true needs and goals.
          3231 руб             2009 год          268 стр.          мягкая обложка

Mediation - Alternative Dispute Resolution. Ein Blick ueber den Tellerrand
Damit richtet sich das Buch an alle Menschen, die an einer konstruktiven Konfliktbewaeltigung teilhaben wollen.
          3231 руб             2008 год          332 стр.          мягкая обложка

Mediation verkaufen. Der Vertrieb von Mediationsdienstleistungen unter besonderer BerA?cksichtigung ihrer Eigenschaften als vertrauensbasierte Dienstleistung
Dabei kommt der Mediation als Innovation in den Augen vieler potenzieller Kunden und Kundinnen besondere Bedeutung zu, da sie den aus dem Marketing bekannten Adoptionsprozess bis zur Kaufentscheidung durchlaufen mA? ssen. Auch das meist eingesetzte Buying Center auf Kundenseite bietet zahlreiche AnsA¤tze fA? r den Mediator bzw. die Mediatorin, die VertrauenshA? rde zu A? berwinden. Dies wird anhand empirischer Umfragedaten und psychologischer, soziologischer sowie wirtschaftswissenschaftlicher Grundlagen erklA¤rt.
          2005 руб             2007 год          108 стр.          мягкая обложка

Formal Mediation Models:. Negotiating their Enabling and Constraining Features
Structuration theory also supports the exploration of the difference between the spirit and the features of a structural system thereby highlighting contradictions that contribute to tensions.
          2413 руб             2009 год          152 стр.          мягкая обложка

Selected antecedents and consequences of team identity. Testing the mediating role of team identity and the moderating role of select personal and social-situational variables
With the advent of valid and reliable survey instruments to assess the motivation, team identity, and team loyalty constructs it is now possible to empirically investigate the mediating role of team identity in the relation between sport fan motives and team loyalty.
          2781 руб             2010 год          164 стр.          мягкая обложка

Mediation (statistics)
While the concept of mediation as defined within psychology is theoretically appealing the methods used to study mediation empirically have been challenged by statisticians and epidemiologists and formally derived by Pearl.
          1188 руб             2010 год          68 стр.          мягкая обложка

Skip James
He worked on road construction and levee-building crews in his native Mississippi in the early 1920s, and wrote what is perhaps his earliest song, "Illinois Blues", about his experiences as a laborer. Later in the ' 20s he sharecropped and made bootleg whiskey in the Bentonia area. High Quality Content by WIKIPEDIA articles! As a youth, James heard local musicians such as Henry Stuckey and brothers Charlie and Jesse Sims and began playing the organ in his teens. Nehemiah Curtis "Skip" James (June 9, 1902 – October 3, 1969) was an American delta blues singer, guitarist, pianist and songwriter. James was born near Bentonia, Mississippi. His father was a converted bootlegger turned preacher.
          1384 руб             2010 год          84 стр.          мягкая обложка


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