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Lead Exposure. Global and Quantitative Gene Expression Analysis of the Effects of Drinking Water Exposure to Lead Acetate in Fisher 344 Male Rats Liver

Автор:   Worlanyo G.
мягкая обложка
276 страниц
2009 год
Издательство:   Книга по Требованию
3231 руб
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Описание:Pb controls mammalian protein synthesis via regulating phosphorylation or dephosphorylation events of eukaryotic elongation/initiation factors; Pb regulates gene expression through the regulation of histone acetylases and Pb regulates calcium dependent transcription factor myocyte enhance factor-2. The primary objective of this work was to analyze global gene expression patterns occurring in Fisher 344 rat livers exposed to varying levels of lead. Results showed differentially expressed genes including genes cited in the literature and several not previously reported to be affected by lead toxicity. Quantitative PCR was employed in validating the microarray result and showed that Microarrays and qRT-PCR yield comparable results. Conclusions include: Pathways emphasized the importance of Pb in modulating various cellular events in a manner similar to calcium regulation, including calcium signaling phosphorylation and dephosphorylation, histone acetylation and deacetylation. Expression profiles were clustered and gene ontology (GO) revealed 15 GO categories affected by chronic (90d) exposure, while 3 GO categories were affected during (30d) exposures.

Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

2990 руб
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Moab is my Washpot

We were not on the water mains in Booton, each day the procedure of ‘pumping up’ had to be gone through. There were two wells, one with hard drinking water from the water table, the other a rainwater collection cistern providing water for washing and bathing. The low tap in the kitchen was the only drinking water tap in the house. Guests, especially Londoners, always commented on the beautiful softness of the water when they bathed – it lathered beautifully and never left the scumline that lime-loaded London water does – but most of them wondered how we could go through the nonsense of daily pumping every day and why, in winter it was always colder inside the house than outside. The pump house had been fitted with an electrically driven motor, I wouldn’t want you to picture Roger and me labouring away like medieval parishioners on the village green. The motor drove enormous wheels which were connected by great belts that slapped away as the pump worked. When we had first arrived at Booton a health inspector had taken a sample of water for analysis (the bottom of the holding tank had been alive with bright red nematodes) ...»

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