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MOLECULAR MECHANISMS OF NITROGLYCERIN BIOACTIVATION. New findings about GTN-derived nitric oxide formation

Автор:   Matteo B.
мягкая обложка
200 страниц
2010 год
Издательство:   Книга по Требованию
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2781 руб
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Описание:This work shows (i) direct NO formation during ALDH2-catalyzed reaction, suggesting 3-electron GTN reduction yielding NO beside 2-electron reduction yielding nitrite; (ii) ALDH2 inactivation during GTN metabolism and its partial restoration by thiols; (iii) co-generation of superoxide, which limits NO bioavailability and might explain nitrate tolerance; (iv) association between ascorbate deficiency-caused nitrate tolerance in guinea pigs and reduced ALDH2 activity; (v) GTN reduction to NO also by cytosolic ALDH1; (vi) non-enzymatic GTN bioactivation by ascorbate; (vii) lack of involvement of the mitochondrial respiratory chain in GTN bioactivation. Nitroglycerin (GTN) is used to treat cardiovascular diseases, as it is believed to act through NO release. Although GTN is considered safe, its continuous administration results in a complete loss of hemodynamic effects (nitrate tolerance), probably due to increased oxidative stress or impaired metabolism, leading to lower NO bioavailability in vasculature. ALDH2 seems to be the key enzyme of GTN bioactivation, although the reaction mechanism is still elusive.


Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

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Структура глобальной катастрофы

New York: McGraw-Hill. 6. Crochat, P. and Franklin, D. (2000.) Back-Propagation Neural Network Tutorial. 7. Deacon, T. 1997. The symbolic species: The co-evolution of language and the brain. New York: Norton. 8. Drexler, K. E. 1992. Nanosystems: Molecular Machinery, Manufacturing, and Computation. New York: Wiley-Interscience. 9. Ekman, P. and Keltner, D. 1997. Universal facial expressions of emotion: an old controversy and new findings. In Nonverbal communication: where nature meets culture, eds. U. Segerstrale and P. Molnar. Mahwah, NJ: Lawrence Erlbaum Associates. 10. Good, I. J. 1965. Speculations Concerning the First Ultraintelligent Machine. Pp. 31-88 in Advances in Computers, vol 6, eds. F. L. Alt and M. Rubinoff. New York: Academic Press. 11. Hayes, J. R. 1981. The complete problem solver. Philadelphia: Franklin Institute Press. 12. Hibbard, B. 2001. Super-intelligent machines. ACM SIGGRAPH Computer Graphics, 35(1). 13. Hibbard, B. 2004. Reinforcement learning as a Context for Integrating AI Research ...»

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