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Cold Thermal Processing in the Spinal Cord. In Search of Therapeutic Targets for Cold Hyperesthesia

Автор:   Paul W.
мягкая обложка
180 страниц
2010 год
Издательство:   Книга по Требованию
Цена:
2781 руб
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Описание:The results of this thesis provide further information on thermal processing, indicate direction for further research and suggest possible therapeutic targets for the management of abnormal cold sensory processing. Two recently identified transient receptor potential (TRP) channels, TRPM8 and TRPA1, have been proposed to play an important role in mammalian cool and cold peripheral sensory transduction. In this thesis an in vitro electrophysiological approach is used to investigate the dorsal horn processing of cool afferent modalities and the role of TRP ion channels. Although these receptors are also transported to the central terminals of primary afferents, little is known about their centrally mediated actions. When expressed in cell-lines the cloned TRPM8 and TRPA1 receptors have distinct pharmacological and temperature response characteristics.


Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

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The Emerging Mind: The Reith Lectures 2003

The pons is a major route by which the forebrain sends information to and receives information from the spinal cord and peripheral nervous system. Q Qualia: A term for subjective sensations. In Phantoms In The Brain, Professor Ramachandran describes the riddle of qualia like this: How can the flux of ions and electrical currents in little specks of jelly the neurons in my brain generate the whole subjective world of sensations like red, warmth, cold or pain? By what magic is matter transmuted into the invisible fabric of feelings and sensations? R Receptor Cell: Specialized sensory cells designed to pick up and transmit sensory information. Receptor Molecule: A specific molecule on the surface or inside of a cell with a characteristic chemical and physical structure. Many neurotransmitters and hormones exert their effects by binding to receptors on cells. Reuptake: A process by which released neurotransmitters are absorbed for subsequent re-use. Rod: A sensory neuron located in the periphery of the retina. It is sensitive to light of low intensity and specialized for nighttime vision ...»

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