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Химия Химия
Органическая химия Органическая химия

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Type 1 Diabetes, Glucocorticoids and the Brain: a sweet connection. How type 1 diabetes affects the brain

Автор:   Yanina R.
мягкая обложка
136 страниц
2009 год
Издательство:   Книга по Требованию
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2413 руб
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Описание:Moreover, the GRs are crucial for the mechanism that underlies the disruption of hippocampal integrity and the impairment of cognitive performance. These data indicate that glucocorticoids play a causal role in diabetes neuropathology. Finally, normalization of the hippocampal dysfunction and the impaired cognition of diabetic mice were achieved using a glucocorticoid receptor (GR) antagonist. The general hypothesis tested that the onset of diabetes induces first dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis and subsequently hypersecretion of glucocorticoids which then renders the brain more vulnerable to metabolic insults causing damage and concomitant cognitive disturbances. Furthermore, diabetic animals present hippocampal pathology suggesting mild neurodegeneration. However the reason why T1D affects CNS integrity remains to be elucidated. Here it is demonstrated that hyperresponsiveness of the adrenal glands is the primary event leading to hypercorticism in diabetic mice. Concurrently, cognitive impairments related to spatial memory were found. Type 1 diabetes (T1D) can impact the integrity of the central nervous system (CNS).


Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

2990 руб
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The Black Swan: The Impact of the Highly Improbable

So we pull memories along causative lines, revising them involuntarily and unconsciously. We continuously renarrate past events in the light of what appears to make what we think of as logical sense after these events occur. By a process called reverberation, a memory corresponds to the strengthening of connections from an increase of brain activity in a given sector of the brainБЂ”the more activity, the stronger the memory. While we believe that the memory is fixed, constant, and connected, all this is very far from truth. What makes sense according to information obtained subsequently will be remembered more vividly. We invent some of our memoriesБЂ”a sore point in courts of law since it has been shown that plenty of people have invented child-abuse stories by dint of listening to theories. The MadmanБЂ™s Narrative We have far too many possible ways to interpret past events for our own good. Consider the behavior of paranoid people. I have had the privilege to work with colleagues who have hidden paranoid disorders that come to the surface on occasion ...»

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The Adam-Christ typology is both comparison and contrast.
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The Effects of Working Memory Capacity and Task Type on Physical Movement I’m Thinking So Hard My Hands Don’t Work.
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Christian Instruction in the History, Types, and Prophecies of the Old Testament
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