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Receptor Specificity and Cellular Entry of Human Rhinoviruses. Receptor recognition and virus entry pathways

Автор:   Abdul G.K.
мягкая обложка
140 страниц
2010 год
Издательство:   Книга по Требованию
Цена:
2413 руб
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Описание:Human rhinoviruses (HRVs), the major cause of the common cold, are classified into two groups on the basis of receptor specificity. Concerning virus entry, where minor group HRVs depend on clathrin-mediated endocytosis, the pathway of major group HRVs and that of HS-binding viruses is largely unknown. Here we provide evidence that there is a increasing trend for the involvement of heparan sulfate (HS) proteoglycans as an alternate receptor. Minor group HRVs use members of the low-density lipoprotein receptor (LDLR) super-family while major group types bind to intercellular adhesion molecule-1 (ICAM-1). Combining immunofluorescence technique with electron microscopy, dominant negative mutants and pharmacological inhibitor assays, we demonstrate that the major group virus (HRV14) enters via dynamin- independent macropinocytosis into RD-ICAM cells whereas virus entry into RD cells via HS exhibits similar characteristics with respect to co- localization with endocytic markers and pharmacological inhibitor profiles. However, this virus entry is dependent on functional dynamin and viruses accumulate in comparatively larger vesicular structures.


Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

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Linux Network Administrator Guide, Second Edition

Comments in the map file generally contain additional information on the sites described in it. There is a rigid format in which to specify this information so that it can be retrieved from the maps. For instance, a program called uuwho uses a database created from the map files to display this information in a nicely formatted way. When you register your site with an organization that distributes map files to its members, you generally have to fill out such a map entry. Below is a sample map entry (in fact, it's the one for Olaf's site): #NPPPPP monad, monad.swb.de, monad.swb.sub.org #SPPPPP AT 486DX50; Linux 0.99 #OPPPPP private #CPPPPP Olaf Kirch #EPPPPP okir@monad.swb.de #PPPPPP Kattreinstr. 38, D-64295 Darmstadt, FRG #LPPPPP 49 52 03 N / 08 38 40 E #UPPPPP brewhq #WPPPPP okir@monad.swb.de (Olaf Kirch); Sun Jul 25 16:59:32 MET DST 1993 # monadPP brewhq(DAILY/2) # Domains monad = monad.swb.de monad = monad.swb.sub.org The whitespace after the first two characters is a tab. The meaning of most of the fields is pretty obvious; you will receive a detailed description from whichever domain you register with ...»

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Карандаши цветные Faber-Castell "Grip", 12 цветов.
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Раздел: Прочие


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