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Modeling and Optimization of Protein Expression. Statistical Methods and Metabolic Flux Analysis for Optimization of Recombinant Protein Production by Fungal Platforms

Автор:   Reza G.
мягкая обложка
180 страниц
2010 год
Издательство:   Книга по Требованию
Цена:
2623 руб
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Описание:This book provides a thorough coverage of theoretical and design aspects of two engineering methodologies to overcome this shortcoming. However, it appears that the combination of trial-and-error experimentation and molecular biology are not sufficient to design an optimum strategy to reach the goal. Special emphasis was placed on the effect of the fermentation medium components of A. niger on a recombinant protein production. A detailed metabolic network comprising intracellular compartments, amino acid catabolism and experimental flux measurements of the key metabolites should be developed and used for optimization purposes. Statistically based experimental designs in a sequential manner were introduced as powerful tools and applied for medium optimization. Scientific methods of enhancing gene expression including genomics, applied molecular biology, metabolic engineering, and combinatorial biosynthesis have been sufficiently developed to make a major impact on recombinant protein production. The proposed strategy should be useful to professionals in the field of biotechnology who seek to understand the response of microorganisms to environmental stimuli.


Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

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Методы статистического анализа исторических текстов (часть 2)

Некоторые методы и результаты анализа перемешанных последовательностей. - Труды семинара по векторному и тензорному анализу. - М., изд-во МГУ, 1988, вып. 23, с. 104-121. 405. Калашников В.В., Носовский Г.В., Фоменко А.Т. Геометрия подвижных конфигураций звезд и датировка Альмагеста. - Проблемы устойчивости стохастических моделей. Труды семинара. - М., ВНИИСИ, 1988, с. 59-78. 406. Fomenko А.Т. Empirico-Statistical Methods in Ordering Narrative Texts. - International Statistical Review. - 1988. - V. 566, No. 3. - P. 279-301. 407. Fomenko A.T., Kalashnikov V.V., Nosovsky G.V. When was Ptolemy's star catalogue in "Almagest"compiled in reality?. Preprint, No. 1989-04, ISSN 0347-2809. Dept. of Math. Chalmers Univ. of Technology, The University of Goteborg. Sweden. 408. Калашников В.В., Носовский Г.В., Фоменко А.Т. Статистический анализ и датировка наблюдений, лежащих в основе звездного каталога из "Альмагеста". - Тезисы докладов 5-й Международной конференции по теории вероятностей и математической статистике. Вильнюс, Интитут математики и кибернетики АН Литовской ССР, 1989, т. 3, с. 271-272. 409. Носовский Г.В., Фоменко А.Т ...»

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