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Statistical Modeling for the Analysis of MALDI-TOF Mass Spectrometry. Approaches dealing with Labeled and Label-free Peptide Applications

Автор:   Qi Z.
мягкая обложка
360 страниц
2011 год
Издательство:   Книга по Требованию
Цена:
3048 руб
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Описание:The first topic is to separate and quantify overlapping peptides for the label-free applications. In such situation, more elaborate statistical modeling approaches need to be developed, to account for the uncertainty caused by the estimation of the masses of the peptides. The key difficulty lies in this topic is how to account for incomplete labeling, non-constant residual variance, etc. Both frequentist and Bayesian approaches are applied. Bayesian analysis becomes the unique choice when non-identifiability issues arise without the incorporation of prior information. The second topic aims towards one of the recently developed labeling techniques-- the enzymatic 18O labeling. Two topics are considered in the analyses. The challenge to this topic is to distinguish the isotopic peaks from different peptides which cause an overlap in a spectrum. The analyses are based on the assumption of unknown peptide sequences. The analsyses involve novel as well as application oritented statistical methodologies applied to the mass spectrometry based proteomics data. This is a new research area in the statistical point of view, and it requires non-routine statistical modeling approaches.


Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

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Expert Tongue Trippers

Young people everywhere are striving to communicate with each other and the world around them-even with their parents. It is the lack of communication which creates the so-called generation gap. Bernard Barber points out in his essay Three Human Females (an analysis of the Kinsey report) that communication actually depends upon much more than sex (the biological factor). Dr. Barber approached the study of human behavior in the following way: Above all things, in the analysis of human behavior of any kind we must free ourselves of the biologistic fallacy. All human behavior has three inherent and inter-related aspects: the biological, the psychological, and the social. We must seek to discover the relative share of influence that each has on any given kind of human behavior. This relative share will vary for different kinds of behavior, though no aspect will ever be totally unimportant. To see that the psychological and social aspects are significant is not to deny the biological influence. We must, of course, avoid also the psychologistic and sociologistic fallacies ...»

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