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Statistical Modeling for the Analysis of MALDI-TOF Mass Spectrometry. Approaches dealing with Labeled and Label-free Peptide Applications

Автор:   Qi Z.
мягкая обложка
360 страниц
2011 год
Издательство:   Книга по Требованию
3048 руб
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Описание:The first topic is to separate and quantify overlapping peptides for the label-free applications. In such situation, more elaborate statistical modeling approaches need to be developed, to account for the uncertainty caused by the estimation of the masses of the peptides. The key difficulty lies in this topic is how to account for incomplete labeling, non-constant residual variance, etc. Both frequentist and Bayesian approaches are applied. Bayesian analysis becomes the unique choice when non-identifiability issues arise without the incorporation of prior information. The second topic aims towards one of the recently developed labeling techniques-- the enzymatic 18O labeling. Two topics are considered in the analyses. The challenge to this topic is to distinguish the isotopic peaks from different peptides which cause an overlap in a spectrum. The analyses are based on the assumption of unknown peptide sequences. The analsyses involve novel as well as application oritented statistical methodologies applied to the mass spectrometry based proteomics data. This is a new research area in the statistical point of view, and it requires non-routine statistical modeling approaches.

Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

2990 руб
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Expert Tongue Trippers

Young people everywhere are striving to communicate with each other and the world around them-even with their parents. It is the lack of communication which creates the so-called generation gap. Bernard Barber points out in his essay Three Human Females (an analysis of the Kinsey report) that communication actually depends upon much more than sex (the biological factor). Dr. Barber approached the study of human behavior in the following way: Above all things, in the analysis of human behavior of any kind we must free ourselves of the biologistic fallacy. All human behavior has three inherent and inter-related aspects: the biological, the psychological, and the social. We must seek to discover the relative share of influence that each has on any given kind of human behavior. This relative share will vary for different kinds of behavior, though no aspect will ever be totally unimportant. To see that the psychological and social aspects are significant is not to deny the biological influence. We must, of course, avoid also the psychologistic and sociologistic fallacies ...»

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Чудо-пеленка для мальчика "Bambola".
Пеленка на липучках создана, чтобы обеспечить спокойный сон малышу. Благодаря липучкам, которые удерживают и не позволяют ребенку
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Models and methods used in the analysis of microarray expression data. Towards the identi?cation of regulatory networks using statistical and information theoretical methods on the mammalian transcriptome
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This analytical methodology should be especially useful to auditory cognition professionals, researchers interested in musical analysis of non-notated music, and composers seeking to gain more insight into musical structures in electroacoustic music in general.
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Modeling the Impacts of Area Closures on the Hawaii Longline Fishery. A Spatial Economic Model Incorporating Fish Movement
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Mass Spectrometry Software
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The Analysis of Intellectual Arithmetic ...
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Несмотря на то, что была проведена серьезная работа по восстановлению первоначального качества издания, на некоторых страницах могут обнаружиться небольшие "огрехи": помарки, кляксы и т. п. Книга представляет собой репринтное издание.
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Novel computational techniques in mass spectrometry based proteomics. Making sense of mass spectrometry data
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A Generalized Cohesive Zone Model Modeling the Peel Test for Pressure Sensitive Adhesives.
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Single-channel seismic profiling and the analysis of multiple events. Estimation of seismic propagation parameters from analysis of reverberatory sequences
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Investigating the Effects of the MnO Additives and Process Conditions on the Relaxor Ferroelectric Ceramics. by Using the Diffuse Phase Transition Models, the Spin-Glass Model and the Modified-Landau Theory on Pb(Fe2/3W1/3)O3-PbTiO3 system
Furthermore, the fitting degree and the physical and mathematical means of the diffuse phase transition model are derived by using the statistic theory.
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Traditionally, police agencies have allocated resources in response to their operational demands or requirements, with the majority of resources being distributed in response to political demands and to public calls for service.
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Vital statistics of the town of Keene, New Hampshire
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