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Molecular dynamics of the gene duplication process. Transcriptional and functional divergence in eukaryotic species

Автор:   Clarence K.Z.
мягкая обложка
140 страниц
2010 год
Издательство:   Книга по Требованию
2277 руб
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Описание:In this book, the molecular duplication process is investigated via aspects of transcriptional regulation and gene function. This book is useful for researchers specialized in areas such as molecular evolution, genomics and bioinformatics. The study of ribosomal protein genes in fruitfly species leads to a novel module-wise stabilizing selection theory. In gene function, in fungi species, it is shown that functional similarities between paralogous genes are higher than in orthologous genes, suggesting convergent evolution among duplicated genes. Both studies provide insights into the fast-evolving nature of transcriptional regulation. In transcriptional regulation, how cis-regulatory elements evolve is studied via a comparative genomics approach in fungi and fruitfly species. Duplication is one of the most important mechanism for evolving gene and genome complexity. The study in fungi species demonstrates that the dominant fate of cis-regulatory elements after duplication is the emergence of new binding sites and asymmetrical loss of ancestral elements in one paralog. The availability of complete genome sequences greatly facilitated its study.

Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка Orthomol Immun Junior Сила иммунитета на страже Вашего ребенка

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AVOID BORING PEOPLE: Lessons from a Life in Science

In their talk they provided strong presumptive evidence that the T antigen was the product of SV4o's A gene, one that functions early in the SV40 life cycle as well as in SV4o-transformed (cancerous) cells. Further studies might soon convincingly show it to be the primary cancer-causing genetic unit on SV4o's small circular chromosome. I spent much of the remainder of the summer on Martha's Vineyard preparing the third edition of The Molecular Biology of the Gene. Next to our old farmhouse was a small barn, whose large central room provided an ideal writing space. I was getting invaluable feedback from several science-oriented Harvard and Radcliffe students, who later extended the glossary and corrected the final proofs. Doing the many needed new illustrations was Keith Roberts, by then running his own plant cell biology lab at the John Innes Institute in Norwich, England. As a postdoc at Cambridge five years before, he had created the new drawings for the second edition as well. Over the following academic year, I was again on leave, working full time at Cold Spring Harbor at a salary identical to what Harvard would have paid me for teaching ...»

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