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Английский языкT cells differentiate in the thymus and then circulate in the peripheral blood, where they are the principal effec tors of cell-mediated immunity. They also function as helper and suppressor cells, by modulating the immune response through their effect on В cells, plasma cells, macrophages, and other T Cells. В cells differentiate in bone marrow. Once activated by contact with an antigen, they differentiate into plasma cells, which synthesize antibodies that are secreted into the blood, intercellular fluid, and lymph. В lymphocytes also give rise to memory cells, which differentiate into plas ma cells only after the second exposure to the antigen. Monocytes vary in diameter from 1518 mm and are the largest of the peripheral blood cells. They constitute 37P% of leukocytes. Monocytes possess an eccentric nucleus. The cytoplasm has a ground-glass appearance and fine azurophilic granules. Monocytes are the precursors for members of the mo-nonuclear phagocyte system, including tissue macrophages (histiocytes), osteoclasts, alveolar macrophages, and Kupffer cells of the liver ...» |
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